Reactome | Negative regulation by 'ub-K420 p-S349 SQSTM1 oligomer:KEAP1:CUL3:RBX1 [cytosol]' p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

Schema > RegulationReference > Entries

created	[InstanceEdit:9759127] Rothfels, Karen, 2021-11-29
dbId	9759126
displayName	Negative regulation by 'ub-K420 p-S349 SQSTM1 oligomer:KEAP1:CUL3:RBX1 [cytosol]' p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
literatureReference	[LiteratureReference:9759063] p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription [LiteratureReference:9766496] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy
modified	[InstanceEdit:9766548] Rothfels, Karen, 2022-02-22
regulatedBy	[NegativeRegulation:9759128] Negative regulation by 'ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]'
schemaClass	RegulationReference

(regulationReference)

Cite Us!