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Entries: RegulationReference
Identifier Name
9840051 Negative gene expression regulation by '(2xp-2S-SMAD3):SMAD4:SP1:EP300 [nucleoplasm]' Expression of the type III TGF-beta receptor is negatively regulated by TGF-beta
9642964 Negative gene expression regulation by '(p-S451-RUNX2:CBFB,RUNX2:CBFB,RUNX2:HDAC6):CDKN1A gene [nucleoplasm]' Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype
9641570 Negative gene expression regulation by '2x(p-STAT5A,p-STAT5B):BRWD1 gene [nucleoplasm]' Histone reader BRWD1 targets and restricts recombination to the Igk locus
9657840 Negative gene expression regulation by 'ABCA1 mRNA:miR-144 RISC [cytosol]' MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor
9641820 Negative gene expression regulation by 'ABCA1 mRNA:miR-26 RISC [cytosol]' MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7
9641516 Negative gene expression regulation by 'ABCA1 mRNA:miR-33 RISC [cytosol]' MiR-33 contributes to the regulation of cholesterol homeostasis
9858298 Negative gene expression regulation by 'AXL3:MITF gene [nucleoplasm]' Developmental mechanisms of stripe patterns in rodents
9707518 Negative gene expression regulation by 'BACH1:MAFK [nucleoplasm]' Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells
9909559 Negative gene expression regulation by 'BHLHE40 dimer [nucleoplasm]' DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter
9909562 Negative gene expression regulation by 'BHLHE40 dimer [nucleoplasm]' Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1
9940978 Negative gene expression regulation by 'Bhlhe40 dimer [nucleoplasm]' A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation
9909563 Negative gene expression regulation by 'Bhlhe40 dimer [nucleoplasm]' DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1
9825763 Negative gene expression regulation by 'CDH1 gene:p-S742 TBX3 [nucleoplasm]' Tbx3 represses E-cadherin expression and enhances melanoma invasiveness
9641613 Negative gene expression regulation by 'CREM:PER1 gene [nucleoplasm]' Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks
9641730 Negative gene expression regulation by 'CRHR2:UCN(83-122) [plasma membrane]' Urocortin 1 reduces food intake and ghrelin secretion via CRF(2) receptors
9911250 Negative gene expression regulation by 'Cipc:p-S-Clock:p-S-Bmal1 [nucleoplasm]' CIPC is a mammalian circadian clock protein without invertebrate homologues
9923148 Negative gene expression regulation by 'Csnk2b [nucleoplasm]' CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock
9851010 Negative gene expression regulation by 'DNMT1 [nucleoplasm]' NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells
9850959 Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]' IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK
9642802 Negative gene expression regulation by 'DREAM complex:CDC25A gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
9641835 Negative gene expression regulation by 'DREAM complex:CDC6 gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
9642011 Negative gene expression regulation by 'DREAM complex:E2F1 gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
9642359 Negative gene expression regulation by 'DREAM complex:PCNA gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
9641974 Negative gene expression regulation by 'DREAM complex:RBL1 gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
9642902 Negative gene expression regulation by 'DREAM complex:TOP2A gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
9641265 Negative gene expression regulation by 'E2F6:(TFDP1,TFDP2):APAF1 gene [nucleoplasm]' E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1
9643017 Negative gene expression regulation by 'E2F6:(TFDP1,TFDP2):BRCA1 gene [nucleoplasm]' E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9
9642627 Negative gene expression regulation by 'E2F6:(TFDP1,TFDP2):CBX5 gene [nucleoplasm]' E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9
9642014 Negative gene expression regulation by 'E2F6:(TFDP1,TFDP2):RAD51 gene [nucleoplasm]' Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription
9641954 Negative gene expression regulation by 'E2F6:(TFDP1,TFDP2):RBBP4 gene [nucleoplasm]' E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9
9641693 Negative gene expression regulation by 'E2F6:(TFDP1.TFDP2):RBBP8 gene [nucleoplasm]' E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9
9642139 Negative gene expression regulation by 'E2F6:TFDP1/2,(E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6) [nucleoplasm]' A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells
9641666 Negative gene expression regulation by 'E2F7,E2F8 dimers:E2F1 Gene [nucleoplasm]' E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression
9907134 Negative gene expression regulation by 'EDN1, EDN3:EDNRB [plasma membrane]' Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression
9642932 Negative gene expression regulation by 'EGR2 [nucleoplasm]' PIASxbeta acts as an activator of Hoxb1 and is antagonized by Krox20 during hindbrain segmentation
9642410 Negative gene expression regulation by 'EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm]' The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway
9642854 Negative gene expression regulation by 'ERBB4s80:TAB2:NCOR1:GFAP gene [nucleoplasm]' Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain
9641839 Negative gene expression regulation by 'ERBB4s80:TAB2:NCOR1:S100B gene [nucleoplasm]' Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain
9642650 Negative gene expression regulation by 'ERF:ETS2 Gene [nucleoplasm]' ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation
9641582 Negative gene expression regulation by 'ESR1:estrogen:AXIN1 gene [nucleoplasm]' RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer
9643014 Negative gene expression regulation by 'ESRRA:PPARG1CB:RUNX2 gene [nucleoplasm]' Estrogen Receptor α (ERα) and Estrogen Related Receptor α (ERRα) are both transcriptional regulators of the Runx2-I isoform
9831024 Negative gene expression regulation by 'Foxc1 [nucleoplasm]' Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract
9792548 Negative gene expression regulation by 'Foxc1 [nucleoplasm]' The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate
9831032 Negative gene expression regulation by 'Foxc2 [nucleoplasm]' Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract
9792552 Negative gene expression regulation by 'Foxc2 [nucleoplasm]' The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate
9833053 Negative gene expression regulation by 'Gbx2:Otx2 gene [nucleoplasm]' A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer
9642206 Negative gene expression regulation by 'Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm]' Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis
9732105 Negative gene expression regulation by 'HDAC1 [nucleoplasm]' colgate/hdac1 Repression of foxd3 expression is required to permit mitfa-dependent melanogenesis
9642954 Negative gene expression regulation by 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:CCNA2 gene [nucleoplasm]' E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex
9641640 Negative gene expression regulation by 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:CDK1 gene [nucleoplasm]' E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex
9641575 Negative gene expression regulation by 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:E2F1 gene [nucleoplasm]' E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex
9641316 Negative gene expression regulation by 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:MYBL2 gene [nucleoplasm]' E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex
9840039 Negative gene expression regulation by 'HELLS' HELLS, a chromatin remodeler is highly expressed in pancreatic cancer and downregulation of it impairs tumor growth and sensitizes to cisplatin by reexpressing the tumor suppressor TGFBR3
9858638 Negative gene expression regulation by 'HINT1:HDAC1:SIN3A:TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm]' The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells
9825765 Negative gene expression regulation by 'HINT1:MITF-M:BCL2 gene [nucleoplasm]' The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells
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