Reactome | Positive gene expression regulation by 'POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm]' Core transcriptional regulatory circuitry in human embryonic stem cells

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Positive gene expression regulation by 'POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm]' Core transcriptional regulatory circuitry in human embryonic stem cells Show undefined attributes

created	[InstanceEdit:9641190] Wu, G, 2019-04-04
dbId	9641771
displayName	Positive gene expression regulation by 'POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm]' Core transcriptional regulatory circuitry in human embryonic stem cells
literatureReference	[LiteratureReference:452538] Core transcriptional regulatory circuitry in human embryonic stem cells [LiteratureReference:452596] Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human [LiteratureReference:452591] Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells [LiteratureReference:452445] Transcriptional regulation of nanog by OCT4 and SOX2 [LiteratureReference:452971] Pluripotential competence of cells associated with Nanog activity [LiteratureReference:452740] Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages [LiteratureReference:452756] A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas [LiteratureReference:480746] Reprogramming towards pluripotency requires AID-dependent DNA demethylation [LiteratureReference:480659] Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions [LiteratureReference:480315] Markers that define stemness in ESC are unable to identify the totipotent cells in human preimplantation embryos [LiteratureReference:2888922] Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors [LiteratureReference:2888933] OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells [LiteratureReference:2888946] Control of ground-state pluripotency by allelic regulation of Nanog [LiteratureReference:452628] Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [LiteratureReference:452948] In silico identification of a core regulatory network of OCT4 in human embryonic stem cells using an integrated approach [LiteratureReference:452731] Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression [LiteratureReference:3270568] Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells [LiteratureReference:5244461] Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming [LiteratureReference:5244470] Single-cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs [LiteratureReference:5244471] Biallelic expression of nanog protein in mouse embryonic stem cells [LiteratureReference:2972933] Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-5638456] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm]'
schemaClass	RegulationReference

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(regulationReference)

[BlackBoxEvent:R-HSA-452838] Expression of NANOG

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