Reactome | Jak2 Phosphorylates Stat5 in Response to Leptin

Schema > Reaction > Entries

Jak2 Phosphorylates Stat5 in Response to Leptin Show undefined attributes

authored	[InstanceEdit:2671737] May, B, 2012-11-24
catalystActivity	[CatalystActivity:2671849] protein tyrosine kinase activity of Lep:p-Lepr:p-Jak2:Stat5 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2671863] May, B, 2012-11-26
dbId	2671843
deleted	[Deleted:9032439] Deletion of instance: 2586551 [Deleted:9032440] Deletion of instance: 5334727
displayName	Jak2 Phosphorylates Stat5 in Response to Leptin
edited	[InstanceEdit:2671737] May, B, 2012-11-24
followingEvent	[Reaction:R-MMU-2671832] Phosphorylated Stat5 Dissociates from Leptin Receptor - Mus musculus
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-2671851] Lep:p-Lepr:p-Jak2:Stat5 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2672288] The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms [LiteratureReference:2672232] Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Jak2 Phosphorylates Stat5 in Response to Leptin
orthologousEvent	[Reaction:R-HSA-2671829] JAK2 Phosphorylates STAT5 in Response to Leptin - Homo sapiens
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-2671860] Lep:p-Lepr:p-Jak2:p-Stat5 [plasma membrane]
precedingEvent	[Reaction:R-MMU-2671831] Phosphorylated Lepr Binds Stat5 - Mus musculus
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4420239] Scherer, Thomas, 2013-08-31 [InstanceEdit:4789050] Gonzalez-Perez, Ruben Rene, 2013-10-26
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2671843
summation	[Summation:2672242] Phosphorylated Jak2 phosphorylates Stat5 (at tyrosine-694 of...

Referrals

(replacementInstances)	[Deleted:9032439] Deletion of instance: 2586551 [Deleted:9032440] Deletion of instance: 5334727
(precedingEvent)	[Reaction:R-MMU-2671832] Phosphorylated Stat5 Dissociates from Leptin Receptor

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