Reactome | IFNG gene expression is stimulated by RUNX1 and inhibited by FOXP3

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IFNG gene expression is stimulated by RUNX1 and inhibited by FOXP3 Show undefined attributes

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9006424] Orlic-Milacic, Marija, 2017-05-16
dbId	9006422
displayName	IFNG gene expression is stimulated by RUNX1 and inhibited by FOXP3
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8877330] RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8877362] IFNG gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8877190] Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IFNG gene expression is stimulated by RUNX1 and inhibited by FOXP3
output	[EntityWithAccessionedSequence:R-HSA-629621] IFNG [extracellular region]
precedingEvent	[Reaction:R-HSA-8877360] RUNX1 binds the IFNG promoter - Homo sapiens [Reaction:R-HSA-8877369] RUNX1 and FOXP3 bind the IFNG gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-8877373] Positive gene expression regulation by 'RUNX1:CBFB:IFNG gene [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-8877375] Negative gene expression regulation by 'RUNX1:CBFB:FOXP3:IFNG gene [nucleoplasm]'
regulationReference	[RegulationReference:9641298] Negative gene expression regulation by 'RUNX1:CBFB:FOXP3:IFNG gene [nucleoplasm]' Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1 [RegulationReference:9642125] Positive gene expression regulation by 'RUNX1:CBFB:IFNG gene [nucleoplasm]' Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9006422
summation	[Summation:9006423] Binding of the RUNX1:CBFB complex to the interferon gamma (I...

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(hasEvent)

[Pathway:R-HSA-8877330] RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

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