Reactome | endopeptidase activity of 26S proteasome [cytosol]

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endopeptidase activity of 26S proteasome [cytosol] Show undefined attributes

activity	[GO_MolecularFunction:1793] endopeptidase activity
catalyzedEvent	[BlackBoxEvent:R-GGA-5687112] MAPK6 is degraded by the 26S proteasome - Gallus gallus [BlackBoxEvent:R-GGA-450466] AUF1:mRNA complex is degraded - Gallus gallus [BlackBoxEvent:R-GGA-9954728] The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide - Gallus gallus [BlackBoxEvent:R-GGA-9755303] 26S proteasome degrades HIFalpha - Gallus gallus [BlackBoxEvent:R-GGA-5668520] 26Sproteasome degrades K48polyUb-NIK - Gallus gallus [BlackBoxEvent:R-GGA-5362448] Hh C-terminal fragments are degraded by the proteasome - Gallus gallus [BlackBoxEvent:R-GGA-9934893] Proteolysis of K48polyUb-K,p-S-PER1,2,3 - Gallus gallus [BlackBoxEvent:R-GGA-9755306] ub UBXN7 is degraded by the 26S proteasome - Gallus gallus [BlackBoxEvent:R-GGA-8866553] misfolded CFTR is degraded by the 26S proteasome - Gallus gallus [BlackBoxEvent:R-GGA-8932355] 26S proteasome degrades Ub-NFE2L2 - Gallus gallus [BlackBoxEvent:R-GGA-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Gallus gallus [BlackBoxEvent:R-GGA-5610760] GLI1 is degraded by the proteasome after ubiquitination by ITCH - Gallus gallus [BlackBoxEvent:R-GGA-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP - Gallus gallus [BlackBoxEvent:R-GGA-5635868] ub-GLI is degraded by the proteasome - Gallus gallus [BlackBoxEvent:R-GGA-5668481] Protesomal degradation of K48polyUb-TRAF3 - Gallus gallus [BlackBoxEvent:R-GGA-1236970] Proteasomal clevage of exogenous antigen (26S proteasome catalyst) - Gallus gallus [BlackBoxEvent:R-GGA-353125] 26S proteosome degrades ODC holoenzyme complex - Gallus gallus [Reaction:R-GGA-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Gallus gallus [Reaction:R-GGA-9931314] Proteasomal degradation of polyUb-p-S195-CD274 - Gallus gallus [Reaction:R-GGA-9929352] Ubiquitinated CD274 is degraded by the 26S proteasome - Gallus gallus [BlackBoxEvent:R-GGA-75825] Proteasome mediated degradation of Cyclin D1 - Gallus gallus [BlackBoxEvent:R-GGA-8854071] Proteasome-mediated degradation of PolyUb-FBXL7 - Gallus gallus [BlackBoxEvent:R-GGA-8854044] Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 - Gallus gallus [BlackBoxEvent:R-GGA-1168640] Ubiquitinated IkB is degraded - Gallus gallus [BlackBoxEvent:R-GGA-69016] Ubiquitinated Cdc6 is degraded by the proteasome - Gallus gallus [BlackBoxEvent:R-GGA-5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex - Gallus gallus [BlackBoxEvent:R-GGA-209061] Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex - Gallus gallus [BlackBoxEvent:R-GGA-5610754] GLI3 is partially degraded by the proteasome to yield the GLI3 repressor - Gallus gallus [BlackBoxEvent:R-GGA-9766223] Proteasome-dependent degradation of ubiquitinated CDH1 - Gallus gallus [BlackBoxEvent:R-GGA-2130282] Degradation of ubiquitinated beta catenin by the proteasome - Gallus gallus [BlackBoxEvent:R-GGA-3640874] Ub-RibC-AXIN is degraded by the proteasome - Gallus gallus [BlackBoxEvent:R-GGA-4641260] Ubiquitinated DVL1 is degraded by the proteasome - Gallus gallus [BlackBoxEvent:R-GGA-1504193] Ubiquitinated DVL is degraded by the proteasome - Gallus gallus [BlackBoxEvent:R-GGA-4641256] Ubiquitinated AXIN is degraded by the proteasome - Gallus gallus [BlackBoxEvent:R-GGA-4608855] PRICKLE1 is degraded by the proteasome - Gallus gallus [BlackBoxEvent:R-GGA-5658430] NF1 is degraded by the proteasome - Gallus gallus [BlackBoxEvent:R-GGA-68948] Ubiquitinated Orc1 is degraded by the proteasome - Gallus gallus [BlackBoxEvent:R-GGA-1234159] Proteasome proteolyzes ub-HIF-alpha - Gallus gallus [BlackBoxEvent:R-GGA-8850992] Proteasome degrades polyubiquitinated PTEN - Gallus gallus [BlackBoxEvent:R-GGA-983150] Proteasomal cleavage of substrate - Gallus gallus [BlackBoxEvent:R-GGA-264458] Proteasome mediated degradation of COP1 - Gallus gallus [BlackBoxEvent:R-GGA-174105] Degradation of multiubiquitinated cell cycle proteins - Gallus gallus [BlackBoxEvent:R-GGA-174202] Degradation of multiubiquitinated Securin - Gallus gallus [BlackBoxEvent:R-GGA-174255] Degradation multiubiquitinated Cyclin A - Gallus gallus
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10732838
displayName	endopeptidase activity of 26S proteasome [cytosol]
physicalEntity	[Complex:R-GGA-68819] 26S proteasome [cytosol]
schemaClass	CatalystActivity

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