Reactome | 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex

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26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex Show undefined attributes

catalystActivity	[CatalystActivity:10732838] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10790163
displayName	26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
eventOf	[Pathway:R-GGA-2871837] FCERI mediated NF-kB activation - Gallus gallus [Pathway:R-GGA-5607764] CLEC7A (Dectin-1) signaling - Gallus gallus [Pathway:R-GGA-202424] Downstream TCR signaling - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-GGA-2730894] NFKB1:RELA translocates from the cytosol to the nucleus - Gallus gallus
inferredFrom	[BlackBoxEvent:R-HSA-5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex - Homo sapiens
input	[Complex:R-GGA-5607697] K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
output	[Complex:R-GGA-194043] NFKB1(1-433):RELA [cytosol]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-5607724
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-5607764] CLEC7A (Dectin-1) signaling [Pathway:R-GGA-2871837] FCERI mediated NF-kB activation [Pathway:R-GGA-202424] Downstream TCR signaling
(precedingEvent)	[BlackBoxEvent:R-GGA-2730894] NFKB1:RELA translocates from the cytosol to the nucleus
(inferredTo)	[BlackBoxEvent:R-HSA-5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex

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