Tom McGirr

 ORCID
https://orcid.org/0009-0008-3549-2080
Reviewed Pathways (4/4)
Date Identifier Pathway Reference
2025-11-07 R-HSA-9948299 Ribosome-associated quality control BibTex
2025-11-07 R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA BibTex
2025-11-07 R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA BibTex
2025-11-07 R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide BibTex
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Reviewed Reactions (15/22)
Date Identifier Reaction Reference
2025-11-07 R-HSA-9955731 ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide BibTex
2025-11-07 R-HSA-9954919 ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released BibTex
2025-11-07 R-HSA-9954730 PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide BibTex
2025-11-07 R-HSA-9954728 The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide BibTex
2025-11-07 R-HSA-9948360 NEMF binds 60S ribosomal subunit:peptidyl-tRNA with nascent peptide BibTex
2025-11-07 R-HSA-9949676 The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer BibTex
2025-11-07 R-HSA-9949632 VCP hexamer extracts K48 polyubiquitinated alanine-tailed nascent peptide from VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide BibTex
2025-11-07 R-SCE-9950051 CDC48 extracts K48 polyubiquitinated Ala-Thr-tailed nascent peptide from CDC48 hexamer:UFD1:NPL4:RKR1:RQC2:RQC1:60S ribosome subunit:K48polyUb-nascent peptide-Ala-Thr BibTex
2025-11-07 R-HSA-9948427 ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide BibTex
2025-11-07 R-HSA-9954721 NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide BibTex
2025-11-07 R-HSA-9954723 NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide BibTex
2025-11-07 R-HSA-9948415 VCP hexamer and NPLOC4:UFD1 bind K48polyubiquitin of LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide BibTex
2025-11-07 R-SCE-9950045 CDC48 hexamer, UFD1, and NPL4 bind K48polyubiquitin of RKR1:RQC2:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide BibTex
2025-11-07 R-HSA-9948362 LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide BibTex
2025-11-07 R-HSA-9954737 RCHY1 K48 polyubiquitinates alanine-tailed nascent peptide BibTex
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