Reactome | NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide

NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide

Stable Identifier

R-HSA-9954721

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide

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The CRL-KLHDC10 E3 ubiquitin ligase complex (NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10) polymerizes ubiquitin monomers with K48 linkages onto exposed lysine residues of an alanine-tailed nascent peptide that has been extracted from a 60S ribosomal subunit (Thrun et al. 2021). The K48-polyubiquitin targets the nascent peptide for degradation by the 26S proteasome (Thrun et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
33909987	Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing Thrun, A, Garzia, A, Kigoshi-Tansho, Y, Patil, PR, Umbaugh, CS, Dallinger, T, Liu, J, Kreger, S, Patrizi, A, Cox, GA, Tuschl, T, Joazeiro, CAP	Mol Cell	2021