The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide

Stable Identifier
R-HSA-9954728
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide
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The K48-polyubiquitinated nascent peptide is proteolytically degraded by the 26S proteasome (Thrun et al. 2021). During the process the PSMD2, ADRM1, and PSMD4 subunits of the 26S proteasome complex bind K48-linked polyubiquitin conjugated to the substrate protein (reviewed in Bard et al. 2018). The PSMD14 subunit of the 26S proteasome deubiquitnates the substrate protein, and the ATP-driven motor activity of the 26S proteasome feeds the substrate protein into the central pore of the proteasome, where the substrate protein is degraded (reviewed in Bard et al. 2018).
Literature References
PubMed ID Title Journal Year
33909987 Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing

Thrun, A, Garzia, A, Kigoshi-Tansho, Y, Patil, PR, Umbaugh, CS, Dallinger, T, Liu, J, Kreger, S, Patrizi, A, Cox, GA, Tuschl, T, Joazeiro, CAP

Mol Cell 2021
Participants
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Output
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as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Bos taurus)
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Caenorhabditis elegans)
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Canis familiaris)
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Danio rerio)
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Dictyostelium discoideum)
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Drosophila melanogaster)
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Gallus gallus)
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Mus musculus)
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Plasmodium falciparum)
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Rattus norvegicus)
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Sus scrofa)
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Xenopus tropicalis)
Authored
May, B  (2025-06-06)
Reviewed
Bennett, EJ  (2025-08-09)
Ford, PW  (2025-08-09)
Jafarnejad, SM  (2025-11-07)
McGirr, T  (2025-11-07)
Created
May, B  (2025-06-08)
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