Reactome | INS [transport vesicle]

INS [transport vesicle]

Stable Identifier

R-SSC-6808712

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

transport vesicle

Synonyms

6xHC-INS(25-110), P01315

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Asparagine N-linked glycosylation (Sus scrofa)
    - Transport to the Golgi and subsequent modification (Sus scrofa)
      - ER to Golgi Anterograde Transport (Sus scrofa)
        
        COPI-mediated anterograde transport (Sus scrofa)
        
        ARFGAPs stimulate ARF GTPase activity (Sus scrofa)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Sus scrofa)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Sus scrofa)
        
        INS [transport vesicle] (Sus scrofa)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Sus scrofa)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Sus scrofa)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Sus scrofa)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Sus scrofa)
        
        INS [transport vesicle] (Sus scrofa)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Sus scrofa)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Sus scrofa)
        
        INS [transport vesicle] (Sus scrofa)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Sus scrofa)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Sus scrofa)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Sus scrofa)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Sus scrofa)
        
        INS [transport vesicle] (Sus scrofa)

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - ER to Golgi Anterograde Transport (Sus scrofa)
    - COPI-mediated anterograde transport (Sus scrofa)
      - ARFGAPs stimulate ARF GTPase activity (Sus scrofa)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Sus scrofa)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Sus scrofa)
        
        INS [transport vesicle] (Sus scrofa)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Sus scrofa)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Sus scrofa)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Sus scrofa)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Sus scrofa)
        
        INS [transport vesicle] (Sus scrofa)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Sus scrofa)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Sus scrofa)
        
        INS [transport vesicle] (Sus scrofa)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Sus scrofa)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Sus scrofa)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Sus scrofa)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Sus scrofa)
        
        INS [transport vesicle] (Sus scrofa)

External Reference Information

External Reference

UniProt:P01315

Gene Names

INS

Reference Genes

BioGPS Gene:397415 INS

ENSEMBL:ENSSSCG00000033740

KEGG:ssc:397415 INS

Monarch:397415 INS

NCBI Gene:397415 INS

UCSC:P01315 INS

Reference Transcript

RefSeq:NM_001109772.2 INS

Other Identifiers

397415

GO:0001819

GO:0002020

GO:0002376

GO:0002674

GO:0003013

GO:0005158

GO:0005159

GO:0005179

GO:0005576

GO:0005615

GO:0006953

GO:0006954

GO:0007186

GO:0008284

GO:0008286

GO:0010628

GO:0010629

GO:0010750

GO:0010976

GO:0032880

GO:0038060

GO:0038202

GO:0042060

GO:0042177

GO:0042311

GO:0042593

GO:0042802

GO:0043123

GO:0043410

GO:0045725

GO:0045727

GO:0045818

GO:0045821

GO:0045840

GO:0045922

GO:0046326

GO:0046628

GO:0046631

GO:0048018

GO:0050708

GO:0050709

GO:0050995

GO:0051897

GO:0055089

GO:0060266

GO:0060267

GO:0098772

GO:1900182

GO:1902952

GO:1903076

GO:1903427

GO:1990535

GO:2000059

GO:2000252

Ssc.583.1.S1_at

Participates

as a member of

ERGIC-to-cis-Golgi cargo [transport vesicle] (Sus scrofa)

Other forms of this molecule

INS [extracellular region]

INS [endosome lumen]

INS [endoplasmic reticulum-Golgi intermediate compartment membrane]

INS [Golgi membrane]

INS [endoplasmic reticulum lumen]

INS [secretory granule lumen]

INS [Golgi lumen]

Inferred From

6xHC-INS(25-110) [transport vesicle] (Homo sapiens)

Modified Residues

Name

Intra-chain Crosslink via L-cystine (cross-link) at 31 and 96 (in Homo sapiens)

Coordinate

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Name

Intra-chain Crosslink via L-cystine (cross-link) at 43 and 109 (in Homo sapiens)

Coordinate

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Name

Intra-chain Crosslink via L-cystine (cross-link) at 95 and 100 (in Homo sapiens)

Coordinate

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Cross References

RefSeq

NP_001103242.1

ENSEMBL

ENSSSCG00000033740, ENSSSCP00000044635, ENSSSCT00000064136

VGNC

99778

PDB

1ZEI, 7AC4, 2G4M, 1B2C, 1B2B, 1M5A, 1B2A, 1B2F, 1ZNI, 1B2E, 1B2G, 7INS, 9INS, 1B2D, 4A7E, 1MPJ, 6INS, 5FB6, 1B17, 1WAV, 1DEI, 3T2A, 3MTH, 3INS, 6Z7Z, 3FHP, 3RTO, 1SDB, 5D5E, 1B19, 1B18, 2TCI, 5D53, 5D52, 4INS, 5D54, 2EFA, 1IZA, 1IZB, 5LIS, 3GKY, 2ZPP

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01315	11	INS [extracellular region] (R-SSC-74673) INS [extracellular region] (R-SSC-74672) INS [endosome lumen] (R-SSC-141723) INS [endosome lumen] (R-SSC-141720) INS [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-SSC-6807734) INS [transport vesicle] (R-SSC-6808712) INS [Golgi membrane] (R-SSC-6808710) INS [endoplasmic reticulum lumen] (R-SSC-264893) INS [endoplasmic reticulum lumen] (R-SSC-265075) INS [secretory granule lumen] (R-SSC-264984) INS [Golgi lumen] (R-SSC-264890)	0.663	3

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