Reactome | SSA1 [nucleoplasm]

SSA1 [nucleoplasm]

Stable Identifier

R-SCE-912480-2

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

HSPA2, P10591

Locations in the PathwayBrowser

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Cellular responses to stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - Cellular response to heat stress (Saccharomyces cerevisiae)
    - HSF1-dependent transactivation (Saccharomyces cerevisiae)
      - Attenuation phase (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1 binds HSF1 (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSPA (HSP70) proteins [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSPA2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SSA1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1:HSF1 trimer:target gene [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSPA (HSP70) proteins [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSPA2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SSA1 [nucleoplasm] (Saccharomyces cerevisiae)
    - Regulation of HSF1-mediated heat shock response (Saccharomyces cerevisiae)
      - SIRT1 binds to HSF1 (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSPA (HSP70) proteins [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSPA2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SSA1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSPA (HSP70) proteins [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSPA2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SSA1 [nucleoplasm] (Saccharomyces cerevisiae)
      - SIRT1 deacetylates HSF1 (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1:HSF1 trimer:target gene [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSPA (HSP70) proteins [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSPA2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SSA1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSPA (HSP70) proteins [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSPA2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SSA1 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P10591

Gene Names

SSA1

Reference Genes

BioGPS Gene:851259 SSA1

ENSEMBL:YAL005C

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YAL005C SSA1

Monarch:851259 SSA1

NCBI Gene:851259 SSA1

SGD:YAL005C

Reference Transcript

RefSeq:NM_001178151.1 SSA1

Other Identifiers

11315_i_at

11316_r_at

11317_s_at

1771860_at

851259

GO:0000049

GO:0000060

GO:0000166

GO:0000209

GO:0000329

GO:0002181

GO:0003674

GO:0003723

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005618

GO:0005634

GO:0005737

GO:0005773

GO:0005829

GO:0005844

GO:0005886

GO:0006457

GO:0006605

GO:0006606

GO:0006616

GO:0006626

GO:0007005

GO:0008150

GO:0009277

GO:0015031

GO:0016020

GO:0016192

GO:0016787

GO:0016887

GO:0017053

GO:0031072

GO:0034620

GO:0035617

GO:0042026

GO:0042221

GO:0043161

GO:0043167

GO:0044183

GO:0045892

GO:0051082

GO:0051085

GO:0051169

GO:0051603

GO:0051787

GO:0055085

GO:0070482

GO:0070647

GO:0072318

GO:0072671

GO:0090344

GO:0140657

GO:0140662

Participates

as a member of

Homologues of HSPA2 [nucleoplasm] (Saccharomyces cerevisiae)

Other forms of this molecule

SSA1 [cytosol]

Inferred From

HSPA2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_009396.2

PRO

P10591

PDB

5LYN, 5Z8I, 5Z8Q, 3LCA

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02829	11	HSP90AA1 [plasma membrane] (R-SCE-534996) HSP90AB1 [secretory granule lumen] (R-SCE-6801477) HSP90AA1 [secretory granule lumen] (R-SCE-6801515) HSP90AB1 [extracellular region] (R-SCE-6806463) HSP90AA1 [extracellular region] (R-SCE-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470) HSP90AB1 [ficolin-1-rich granule lumen] (R-SCE-6801491) HSP90AB1 [cytosol] (R-SCE-419617) HSP90AA1 [nucleoplasm] (R-SCE-5082401) HSP90AB1 [nucleoplasm] (R-SCE-5082399) HSP90AA1 [cytosol] (R-SCE-192864)	0.744	5
UniProt:Q12118 SGT2	2	SGT2 [cytosol] (R-SCE-9629049) SGT2 [cytosol] (R-SCE-5423595)	0.744	4
UniProt:P14680	3	monoSUMO1-K32-HIPK2 [nucleoplasm] (R-SCE-4090405) HIPK2 [nucleoplasm] (R-SCE-3215222) HIPK1 [nucleoplasm] (R-SCE-3215224)	0.643	3
UniProt:P29547	1	CAM1 [cytosol] (R-SCE-156925)	0.643	3
UniProt:Q08972	1	ABCF1 [cytosol] (R-SCE-5216139)	0.643	3
UniProt:P00546	8	phospho-p-T160-CDK2 [nucleoplasm] (R-SCE-187967) CDK2 [nucleoplasm] (R-SCE-68365) CDK2 [cytosol] (R-SCE-157440) CDK6 [nucleoplasm] (R-SCE-141283) CDK4 [nucleoplasm] (R-SCE-113843) CDK6 [cytosol] (R-SCE-68336) CDK4 [cytosol] (R-SCE-68330) phospho-p-CDK2 [nucleoplasm] (R-SCE-68370)	0.59	2
UniProt:P06786	4	monoSUMO1-K-TOP2B [nucleoplasm] (R-SCE-4641297) TOP2B [nucleoplasm] (R-SCE-4641359) monoSUMO1-K-TOP2A [nucleoplasm] (R-SCE-4641367) TOP2A [nucleoplasm] (R-SCE-1362276)	0.527	2
UniProt:Q08920	2	NCBP2 [cytosol] (R-SCE-162458) NCBP2 [nucleoplasm] (R-SCE-51463)	0.527	2
UniProt:P15303	4	phospho-p-S738,T744 SEC23A [cytosol] (R-SCE-5685740) SEC23A [ER to Golgi transport vesicle membrane] (R-SCE-204024) SEC23A [cytosol] (R-SCE-203972) SEC23A [endoplasmic reticulum membrane] (R-SCE-203976)	0.527	2
UniProt:P32324 EFT1	11	Me3K525-EEF2 [cytosol] (R-SCE-8932237) diphthine EFT1 [cytosol] (R-SCE-5367015) Me-diphthine EFT1 [cytosol] (R-SCE-5367013) diphthine EEF2 [cytosol] (R-SCE-5358501) nascent EEF2 [cytosol] (R-SCE-5358472) Me-diphthine EEF2 [cytosol] (R-SCE-5367025) EEF2 [ficolin-1-rich granule lumen] (R-SCE-6801513) EEF2 [extracellular region] (R-SCE-6806499) EEF2 [secretory granule lumen] (R-SCE-6801504) EEF2 [cytosol] (R-SCE-156901) aminocarboxypropyl EEF2 [cytosol] (R-SCE-5358478)	0.527	3
UniProt:P32855	1	SEC8 [plasma membrane] (R-SCE-264989)	0.527	2
UniProt:P32471	2	EFB1 [cytosol] (R-SCE-156926) EFB1 [cytosol] (R-SCE-156914)	0.527	2
UniProt:P16603	9	NOS2 [peroxisomal matrix] (R-SCE-9033124) phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-SCE-202139) MyrG-NOS3 [Golgi membrane] (R-SCE-534995) MyrG-NOS3 [cytosol] (R-SCE-203687) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-SCE-203769) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-SCE-534993) NOS1 [cytosol] (R-SCE-419293) NOS2 [cytosol] (R-SCE-202107) NOS3 [cytosol] (R-SCE-202114)	0.527	2
UniProt:P25037	2	UBP1 [mitochondrial outer membrane] (R-SCE-5696931) UBP1 [peroxisomal membrane] (R-SCE-9674135)	0.527	2
UniProt:P15705	1	STI1 [cytosol] (R-SCE-443857)	0.527	2
UniProt:Q12447	1	PAA1 [cytosol] (R-SCE-209813)	0.527	2
UniProt:P36070	1	RRN3 [nucleoplasm] (R-SCE-73714)	0.527	2
UniProt:Q04958	1	PNPLA6 [endoplasmic reticulum membrane] (R-SCE-1498821)	0.527	2
UniProt:P25694	7	VCP [cytosol] (R-SCE-1181251) VCP [ficolin-1-rich granule lumen] (R-SCE-6800425) VCP [extracellular region] (R-SCE-6806191) VCP [secretory granule lumen] (R-SCE-6801039) VCP [azurophil granule lumen] (R-SCE-6800438) VCP [nucleoplasm] (R-SCE-5643745) Me3K315-VCP [cytosol] (R-SCE-8932209)	0.527	2
UniProt:P38431	1	EIF5 [cytosol] (R-SCE-72616)	0.527	2
UniProt:P12385 SUP45	3	Erf-1 [cytosol] (R-SCE-141665) SUP45 [cytosol] (R-SCE-6800157) SUP45 [cytosol] (R-SCE-54433)	0.527	2
UniProt:P22147 XRN1	2	XRN1_YEAST [cytosol] (R-SCE-429980) XRN1 [cytosol] (R-SCE-429835)	0.527	2
UniProt:P38972	1	PFAS [cytosol] (R-SCE-62500)	0.527	2
UniProt:P40344	8	ATG3 [cytosol] (R-SCE-5671860) CysO264-ATG3-MAP1LC3A [cytosol] (R-SCE-9819371) CysO264-ATG3-GABARAP [cytosol] (R-SCE-9819379) CysO264-ATG3-GABARAPL2 [cytosol] (R-SCE-9819376) CysO264-ATG3-MAP1LC3C [cytosol] (R-SCE-9819377) CysO264-ATG3-GABARAPL1 [cytosol] (R-SCE-9819381) CysO264-ATG3-MAP1LC3B [cytosol] (R-SCE-9819365) CysO264-ATG3-GABARAPL3 [cytosol] (R-SCE-5683569)	0.527	2
UniProt:Q12505	3	CHEK1 [cytosol] (R-SCE-205285) CHEK1 [nucleoplasm] (R-SCE-113826) phospho-p-S317,S345-CHEK1 [nucleoplasm] (R-SCE-113838)	0.527	2
UniProt:P34216	2	ITSN2 [cytosol] (R-SCE-8862264) ITSN1 [cytosol] (R-SCE-3006481)	0.527	2
UniProt:P29055	1	GTF2B [nucleoplasm] (R-SCE-65888)	0.527	2
UniProt:P43558	1	YOD1 [cytosol] (R-SCE-6781909)	0.527	3
UniProt:Q01217	1	ARG5,6 [mitochondrial matrix] (R-SCE-70528)	0.527	2
UniProt:Q00955	6	phospho-Btn-p-S222-ACACB [mitochondrial outer membrane] (R-SCE-8876892-2) ACACB [cytosol] (R-SCE-52493-2) ACACA [cytosol] (R-SCE-1660609) Btn-ACACA [cytosol] (R-SCE-2976730) ACACB [mitochondrial outer membrane] (R-SCE-4167505-2) Btn-ACACB [mitochondrial outer membrane] (R-SCE-2993858-2)	0.527	2

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