TRM8:TRM82 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46

Stable Identifier
R-SCE-6790175
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TRM8:TRM82 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46
The TRM8:TRM82 complex transfers a methyl group from S-adenosylmethionine to guanosine-46 of tRNA(Phe), yielding 7-methylguanosine-46 (Alexandrov et al. 2002, Alexandrov et al. 2005, Matsumoto et al. 2007).
Literature References
PubMed ID Title Journal Year
17382321 RNA recognition mechanism of eukaryote tRNA (m7G46) methyltransferase (Trm8-Trm82 complex)

Matsumoto, K, Toyooka, T, Tomikawa, C, Ochi, A, Takano, Y, Takayanagi, N, Endo, Y, Hori, H

FEBS Lett. 2007
12403464 Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA

Alexandrov, A, Martzen, MR, Phizicky, EM

RNA 2002
15811913 tRNA m7G methyltransferase Trm8p/Trm82p: evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8p

Alexandrov, A, Grayhack, EJ, Phizicky, EM

RNA 2005
Participants
Input
Output
Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA (guanine(46)-N7)-methyltransferase activity of TRM8:TRM82 [nucleoplasm]

Physical Entity
TRM8:TRM82 [nucleoplasm] (Saccharomyces cerevisiae)
Activity
tRNA (guanine(46)-N7)-methyltransferase activity (GO:0008176)
Orthologous Events
METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46 (Homo sapiens)
Authored
May, B  (2015-08-08)
Reviewed
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-08-09)
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