TRM8:TRM82 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46

Stable Identifier
R-SCE-6790175
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TRM8:TRM82 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46
The TRM8:TRM82 complex transfers a methyl group from S-adenosylmethionine to guanosine-46 of tRNA(Phe), yielding 7-methylguanosine-46 (Alexandrov et al. 2002, Alexandrov et al. 2005, Matsumoto et al. 2007).
Literature References
PubMed ID Title Journal Year
17382321 RNA recognition mechanism of eukaryote tRNA (m7G46) methyltransferase (Trm8-Trm82 complex)

Toyooka, T, Takayanagi, N, Endo, Y, Takano, Y, Ochi, A, Hori, H, Matsumoto, K, Tomikawa, C

FEBS Lett. 2007
12403464 Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA

Phizicky, EM, Martzen, MR, Alexandrov, A

RNA 2002
15811913 tRNA m7G methyltransferase Trm8p/Trm82p: evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8p

Phizicky, EM, Grayhack, EJ, Alexandrov, A

RNA 2005
Participants
Input
Output
Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA (guanine-N7-)-methyltransferase activity of TRM8:TRM82 [nucleoplasm]

Physical Entity
TRM8:TRM82 [nucleoplasm] (Saccharomyces cerevisiae)
Activity
tRNA (guanine-N7-)-methyltransferase activity (GO:0008176)
Orthologous Events
METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46 (Homo sapiens)
Authored
May, B  (2015-08-08)
Reviewed
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-08-09)
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