METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46

Stable Identifier
R-HSA-6782286
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46
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The METTL1:WDR4 complex transfers a methyl group from S-adenosylmethionine to guanosine-46 of tRNA(Phe), yielding 7-methylguanosine-46 (Alexandrov et al. 2002, Cartlidge et al. 2005). A homologous complex, Trm8p:Trm82p, exists in Saccharomyces cerevisiae and catalyzes the same reaction.
Literature References
PubMed ID Title Journal Year
15861136 The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells

Cartlidge, RA, Knebel, A, Peggie, M, Alexandrov, A, Phizicky, EM, Cohen, P

EMBO J. 2005
12403464 Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA

Alexandrov, A, Martzen, MR, Phizicky, EM

RNA 2002
Participants
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Output
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA (guanine(46)-N7)-methyltransferase activity of METTL1:WDR4 [nucleoplasm]

Physical Entity
METTL1:WDR4 [nucleoplasm] (Homo sapiens)
Activity
tRNA (guanine(46)-N7)-methyltransferase activity (GO:0008176)
Inferred From
TRM8:TRM82 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46 (Saccharomyces cerevisiae)
Authored
May, B  (2015-06-06)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-06)
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