Ttf-I:rRNA Promoter:Ercc6:Ehmt2 complex dimethylates histone H3 at lysine-9

Stable Identifier
R-NUL-573373
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
General
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Ttf-I:rRNA Promoter:Ercc6:Ehmt2 complex dimethylates histone H3 at lysine-9
Ehmt2 (histone methyltransferase G9a) dimethylates histone H3 at lysine-9 in the transcribed region of the rRNA gene (Yuan et al. 2007). Dimethylation of histone H3 in the transcribed region causes increased rRNA expression. ATPase activity of the Chd4 subunit of the NuRD complex is required to activate transcription by repositioning a nucleosome in the promoter region of an rRNA gene (Xie et al. 2012).
Literature References
PubMed ID Title Journal Year
17707230 Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a

Zhou, Y, Grummt, I, Feng, W, Yuan, X, Imhof, A

Mol Cell 2007
22570494 The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions

Zhu, Q, Feng, W, Zhou, Y, Ling, T, Stunnenberg, HG, Xie, W, Tao, W, Grummt, I

Proc. Natl. Acad. Sci. U.S.A. 2012
Participants
Input
Output
Catalyst Activity

histone methyltransferase activity (H3-K9 specific) of Ttf-I:rDNA:CSB:G9a:NuRD [nucleoplasm]

Physical Entity
Ttf-I:rDNA:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
Activity
histone methyltransferase activity (H3-K9 specific) (GO:0046974)
Orthologous Events
TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. (Homo sapiens)
Authored
May, B  (2010-04-06)
Reviewed
Iben, S  (2016-02-12)
Created
May, B  (2010-04-10)
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