TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.

Stable Identifier
R-HSA-427336
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
TTF-I;rRNA Promoter:CSB:G9a Complex Dimethylates Histone H3 at lysine-9
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As inferred from mouse, EHMT2 (histone methyltransferase G9a) dimethylates histone H3 at lysine-9 (H3K9me2) in the transcribed region of the rRNA gene. Dimethylation of histone H3 in the transcribed region causes increased rRNA expression, which contrasts with the repressive effect of H3K9me2 in other regions of the genome. The histone binding activity and ATPase activity of CHD4 in the NuRD complex are also needed for activation.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone methyltransferase activity (H3-K9 specific) of TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created
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