Gro binds Aes

Stable Identifier
R-NUL-4649029
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Gro binds Aes
Aes is a naturally occuring truncated version of Groucho/TLE containing only the Q and GP domains that has been shown to have dominant negative function (Miyasaka et al, 1993; Roose et al, 1998; Ren et al, 1999). Aes is believed to form non-functional oligomers with Groucho/TLE mediated by interactions between the Q domains. In support of this notion, wild-type mouse Aes co-immunoprecipitates with Groucho, but a version of Aes lacking the Q domain does not (Muhr et al, 2001).
Literature References
PubMed ID Title Journal Year
11290324 Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube

Muhr, J, Andersson, E, Persson, M, Jessell, TM, Ericson, J

Cell 2001
9783587 The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

Roose, J, Molenaar, M, Peterson, J, Hurenkamp, J, Brantjes, H, Moerer, P, van De Wetering, M, Destrée, O, Clevers, HC

Nature 1998
Participants
Input
Output
Orthologous Events
TLE forms non-functional complexes with AES (Homo sapiens)
Authored
Rothfels, K  (2013-09-28)
Reviewed
Rajakulendran, N  (2014-01-22)
Created
Rothfels, K  (2013-10-01)
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