Gro binds Aes

Stable Identifier
R-NUL-4649029
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Gro binds Aes
Aes is a naturally occuring truncated version of Groucho/TLE containing only the Q and GP domains that has been shown to have dominant negative function (Miyasaka et al, 1993; Roose et al, 1998; Ren et al, 1999). Aes is believed to form non-functional oligomers with Groucho/TLE mediated by interactions between the Q domains. In support of this notion, wild-type mouse Aes co-immunoprecipitates with Groucho, but a version of Aes lacking the Q domain does not (Muhr et al, 2001).
Literature References
PubMed ID Title Journal Year
11290324 Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube

Jessell, TM, Persson, M, Andersson, E, Ericson, J, Muhr, J

Cell 2001
9783587 The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

van De Wetering, M, Hurenkamp, J, Moerer, P, Clevers, HC, Peterson, J, Destrée, O, Brantjes, H, Roose, J, Molenaar, M

Nature 1998
Participants
Input
Output
Orthologous Events
TLE forms non-functional complexes with AES (Homo sapiens)
Authored
Rothfels, K  (2013-09-28)
Reviewed
Rajakulendran, N  (2014-01-22)
Created
Rothfels, K  (2013-10-01)
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