TLE forms non-functional complexes with AES

Stable Identifier
Homo sapiens
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AES is a naturally occuring truncated form of TLE that contains only the Q and GP domain. AES has been shown to have a dominant negative effect on TLE-mediated repression (Miyasaka et al, 1993; Roose et al, 1998; Ren et al, 1999; Swingler et al, 2004). AES is believed to form oligomers with full length TLE proteins mediated by the Q domains; because AES is unable to interact with HDAC1, these oligomers are thought to be non-functional (Muhr et al, 2001; Brantjes et al, 2001).

Literature References
PubMed ID Title Journal Year
15187083 The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cells

Yao, J, Jayaraman, PS, Bess, KL, Swingler, TE, Stifani, S

J. Biol. Chem. 2004
11290324 Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube

Jessell, TM, Persson, M, Andersson, E, Ericson, J, Muhr, J

Cell 2001
11266540 All Tcf HMG box transcription factors interact with Groucho-related co-repressors

van De Wetering, M, Clevers, HC, Brantjes, H, Roose, J

Nucleic Acids Res. 2001
8365415 Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein

Li, SS, Choudhury, BK, Miyasaka, H, Hou, EW

Eur. J. Biochem. 1993
9887105 PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins

Kim, TH, Ren, B, Chee, KJ, Maniatis, T

Genes Dev. 1999
9783587 The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

van De Wetering, M, Hurenkamp, J, Moerer, P, Clevers, HC, Peterson, J, Destrée, O, Brantjes, H, Roose, J, Molenaar, M

Nature 1998
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