AES is a naturally occuring truncated form of TLE that contains only the Q and GP domain. AES has been shown to have a dominant negative effect on TLE-mediated repression (Miyasaka et al, 1993; Roose et al, 1998; Ren et al, 1999; Swingler et al, 2004). AES is believed to form oligomers with full length TLE proteins mediated by the Q domains; because AES is unable to interact with HDAC1, these oligomers are thought to be non-functional (Muhr et al, 2001; Brantjes et al, 2001).
Muhr, J, Andersson, E, Persson, M, Jessell, TM, Ericson, J
Swingler, TE, Bess, KL, Yao, J, Stifani, S, Jayaraman, PS
Brantjes, H, Roose, J, van De Wetering, M, Clevers, HC
Miyasaka, H, Choudhury, BK, Hou, EW, Li, SS
Ren, B, Chee, KJ, Kim, TH, Maniatis, T
Roose, J, Molenaar, M, Peterson, J, Hurenkamp, J, Brantjes, H, Moerer, P, van De Wetering, M, Destrée, O, Clevers, HC
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