AES is a naturally occuring truncated form of TLE that contains only the Q and GP domain. AES has been shown to have a dominant negative effect on TLE-mediated repression (Miyasaka et al, 1993; Roose et al, 1998; Ren et al, 1999; Swingler et al, 2004). AES is believed to form oligomers with full length TLE proteins mediated by the Q domains; because AES is unable to interact with HDAC1, these oligomers are thought to be non-functional (Muhr et al, 2001; Brantjes et al, 2001).
Yao, J, Jayaraman, PS, Bess, KL, Swingler, TE, Stifani, S
Jessell, TM, Persson, M, Andersson, E, Ericson, J, Muhr, J
van De Wetering, M, Clevers, HC, Brantjes, H, Roose, J
Li, SS, Choudhury, BK, Miyasaka, H, Hou, EW
Kim, TH, Ren, B, Chee, KJ, Maniatis, T
van De Wetering, M, Hurenkamp, J, Moerer, P, Clevers, HC, Peterson, J, Destrée, O, Brantjes, H, Roose, J, Molenaar, M
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