Reactome | TLE forms non-functional complexes with AES

TLE forms non-functional complexes with AES

Stable Identifier

R-HSA-4649028

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

TLE forms non-functional complexes with AES

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

AES is a naturally occuring truncated form of TLE that contains only the Q and GP domain. AES has been shown to have a dominant negative effect on TLE-mediated repression (Miyasaka et al, 1993; Roose et al, 1998; Ren et al, 1999; Swingler et al, 2004). AES is believed to form oligomers with full length TLE proteins mediated by the Q domains; because AES is unable to interact with HDAC1, these oligomers are thought to be non-functional (Muhr et al, 2001; Brantjes et al, 2001).

Literature References

PubMed ID	Title	Journal	Year
15187083	The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cells Swingler, TE, Bess, KL, Yao, J, Stifani, S, Jayaraman, PS	J. Biol. Chem.	2004
11290324	Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube Muhr, J, Andersson, E, Persson, M, Jessell, TM, Ericson, J	Cell	2001
11266540	All Tcf HMG box transcription factors interact with Groucho-related co-repressors Brantjes, H, Roose, J, van De Wetering, M, Clevers, HC	Nucleic Acids Res.	2001
8365415	Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein Miyasaka, H, Choudhury, BK, Hou, EW, Li, SS	Eur. J. Biochem.	1993
9887105	PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins Ren, B, Chee, KJ, Kim, TH, Maniatis, T	Genes Dev.	1999
9783587	The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors Roose, J, Molenaar, M, Peterson, J, Hurenkamp, J, Brantjes, H, Moerer, P, van De Wetering, M, Destrée, O, Clevers, HC	Nature	1998