Ehmt1,Ehmt2 trimethylates lysine-16 of Atf7ip

Stable Identifier
R-MMU-9844112
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ehmt1,Ehmt2 trimethylates lysine-16 of Atf7ip
Either Ehmt2 (also called G9a) or Ehmt1 (also called GLP) can trimethylate lysine-16 of Atf7ip (Tsusaka et al. 2018). Lysine-16 of Atf7ip is located in a domain that mimics lysine-9 of histone H3, which is also methylated by Ehmt2 and Ehmt1. Trimethylation of Atf7ip is required for interaction of Atf7ip with Mphosph8 of the HUSH complex (Tsusaka et al. 2018).
Literature References
PubMed ID Title Journal Year
30286792 Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8

Tsusaka, T, Kikuchi, M, Shimazu, T, Suzuki, T, Sohtome, Y, Akakabe, M, Sodeoka, M, Dohmae, N, Umehara, T, Shinkai, Y

Epigenetics Chromatin 2018
Participants
Input
Output
Catalyst Activity

protein-lysine N-methyltransferase activity of Ehmt1,2 [nucleoplasm]

Physical Entity
Ehmt1,2 [nucleoplasm] (Mus musculus)
Activity
protein-lysine N-methyltransferase activity (GO:0016279)
Orthologous Events
EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP (Homo sapiens)
Authored
May, B  (2023-09-12)
Reviewed
Bourc'his, D  (2024-05-14)
Fernandes, LP  (2024-05-14)
Created
May, B  (2023-09-12)
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