Nudt8 hydrolyzes CoA-SH to PPANT

Stable Identifier
R-MMU-9837342
Type
Reaction [transition]
Species
Mus musculus
Compartment
mitochondrial matrix
Synonyms
CoA + H2O => (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
ReviewStatus
5/5
General
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Nudt8 hydrolyzes CoA-SH to PPANT
Nudt8 in the mitochondrial matrix catalyzes the hydrolysis of Coenzyme A (CoA-SH) to (R)-4'-phosphopantetheine (PPANT) and adenosine 3',5'-bisphosphate (PAP). The enzyme is most abundant in the kidneys, heart, brown adipose tissue, and liver and detectable at lower levels in the brain, skeletal muscle, and white adipose tissue. Its mitochondrial localization has been demonstrated by examination of cultured cells expressing tagged Nudt8 and by enzymatic assays of partially purified liver mitochondria (Kerr et al. 2019).
Literature References
PubMed ID Title Journal Year
31004344 Nudt8 is a novel CoA diphosphohydrolase that resides in the mitochondria

Kerr, EW, Shumar, SA, Leonardi, R

FEBS Lett 2019
Participants
Input
Output
Catalyst Activity

coenzyme A diphosphatase activity of Nudt8 [mitochondrial matrix]

Physical Entity
Nudt8 [mitochondrial matrix] (Mus musculus)
Activity
coenzyme A diphosphatase activity (GO:0010945)
Orthologous Events
NUDT8 hydrolyzes CoA-SH to PPANT (Homo sapiens)
Authored
D'Eustachio, P  (2023-06-13)
Reviewed
Hill, DP  (2023-07-26)
Created
D'Eustachio, P  (2023-06-13)
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