NUDT8 hydrolyzes CoA-SH to PPANT

Stable Identifier
R-HSA-9837354
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
CoA + H2O => (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
ReviewStatus
5/5
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NUDT8 hydrolyzes CoA-SH to PPANT
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Human NUDT8 protein has not been characterized experimentally. Its mitochondrial localization and ability to hydrolyze Coenzyme A (CoA-SH) to (R)-4'-phosphopantetheine (PPANT) and adenosine 3',5'-bisphosphate (PAP) are inferred from properties of Nudt8, its mouse ortholog (Kerr et al. 2019).
Literature References
PubMed ID Title Journal Year
31004344 Nudt8 is a novel CoA diphosphohydrolase that resides in the mitochondria

Kerr, EW, Shumar, SA, Leonardi, R

FEBS Lett 2019
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Catalyst Activity

coenzyme A diphosphatase activity of NUDT8 [mitochondrial matrix]

Physical Entity
NUDT8 [mitochondrial matrix] (Homo sapiens)
Activity
coenzyme A diphosphatase activity (GO:0010945)
Inferred From
Nudt8 hydrolyzes CoA-SH to PPANT (Mus musculus)
Cross References
Rhea
Authored
D'Eustachio, P  (2023-06-13)
Reviewed
Hill, DP  (2023-07-26)
Created
D'Eustachio, P  (2023-06-13)
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