p-T-Eif2ak1:ferriheme dimer autophosphorylates

Stable Identifier
R-MMU-9655549
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-T-Eif2ak1:ferriheme dimer autophosphorylates
During heme deficiency Eif2ak1 (HRI) autophosphorylates, notably on threonine residues in the activation loop (Bauer et al. 2001, Rafie-Kolpin et al. 2003, Igarashi et al. 2011). Eif2ak1 also has many phosphorylated residues prior to activation in response to heme deficiency (Bauer et al. 2001). Autophosphorylation of threonine-485 is essential for kinase activity of Eif2ak1 on Eif2s1 (eIF2-alpha) in response to heme deficiency and oxidative stress by arsenite (Rafie-Kolpin et al. 2003, Igarashi et al. 2011).
Literature References
PubMed ID Title Journal Year
11560503 Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase

Bauer, BN, Rafie-Kolpin, M, Lu, L, Han, A, Chen, JJ

Biochemistry 2001
21223507 Autophosphorylation of heme-regulated eukaryotic initiation factor 2α kinase and the role of the modification in catalysis

Igarashi, J, Sasaki, T, Kobayashi, N, Yoshioka, S, Matsushita, M, Shimizu, T

FEBS J. 2011
12767237 Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI

Rafie-Kolpin, M, Han, AP, Chen, JJ

Biochemistry 2003
Participants
Input
Output
Orthologous Events
p-T-EIF2AK1:ferriheme dimer autophosphorylates (Homo sapiens)
Authored
May, B  (2019-07-24)
Reviewed
Chen, JJ  (2019-10-22)
Created
May, B  (2019-07-24)
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