p-T-EIF2AK1:ferriheme dimer autophosphorylates

Stable Identifier
R-HSA-9648883
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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During heme deficiency, EIF2AK1 (HRI) autophosphorylates, notably on threonine residues in the activation loop (inferred from the mouse homolog). EIF2AK1 also has many phosphorylated residues prior to activation in response to heme deficiency (inferred from the mouse homolog). Autophosphorylation of threonine-488 (threonine-485 in the mouse homolog) is essential for kinase activity of EIF2AK1 acting on EIF2S1 (eIF2-alpha) in response to heme deficiency and oxidative stress by arsenite (inferred from the mouse homolog).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T-EIF2AK1:ferriheme dimer [cytosol]
Physical Entity
Activity
Inferred From
Authored
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