Reactome | p-T,T483,T485-Eif2ak1:ferriheme dimer [cytosol]

p-T,T483,T485-Eif2ak1:ferriheme dimer [cytosol]

Stable Identifier

R-MMU-9655567

Type

Complex

Species

Mus musculus

Compartment

cytosol

Literature References

PubMed ID	Title	Journal	Year
11560503	Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase Bauer, BN, Rafie-Kolpin, M, Lu, L, Han, A, Chen, JJ	Biochemistry	2001
12767237	Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI Rafie-Kolpin, M, Han, AP, Chen, JJ	Biochemistry	2003
17597215	Identification of Cys385 in the isolated kinase insertion domain of heme-regulated eIF2 alpha kinase (HRI) as the heme axial ligand by site-directed mutagenesis and spectral characterization Hirai, K, Martinkova, M, Igarashi, J, Saiful, I, Yamauchi, S, El-Mashtoly, S, Kitagawa, T, Shimizu, T	J. Inorg. Biochem.	2007
18450746	Elucidation of the heme binding site of heme-regulated eukaryotic initiation factor 2alpha kinase and the role of the regulatory motif in heme sensing by spectroscopic and catalytic studies of mutant proteins Igarashi, J, Murase, M, Iizuka, A, Pichierri, F, Martinkova, M, Shimizu, T	J. Biol. Chem.	2008
16893190	Characterization of heme-regulated eIF2alpha kinase: roles of the N-terminal domain in the oligomeric state, heme binding, catalysis, and inhibition Miksanova, M, Igarashi, J, Minami, M, Sagami, I, Yamauchi, S, Kurokawa, H, Shimizu, T	Biochemistry	2006

Participants

components

x 2 p-T,T483,T485-Eif2ak1:ferriheme [cytosol] (Mus musculus)

Participates

as an output of

p-T-Eif2ak1:ferriheme dimer autophosphorylates (Mus musculus)

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