Reactome | Traf6 [endosome membrane]

Traf6 [endosome membrane]

Stable Identifier

R-MMU-450227

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

endosome membrane

Synonyms

K63polyUb-TRAF6, P70196

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P70196-1 Traf6

Gene Names

Traf6

Participates

as a component of

p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Mus musculus)

Other forms of this molecule

Traf6 [cytosol]

TNF receptor associated factor 6 isoform 1 [cytosol]

Traf6 [endosome membrane]

Traf6 [plasma membrane]

Traf6 [cytosol]

Inferred From

K63polyUb-TRAF6 [endosome membrane] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [endosome membrane]) at 124 (in Homo sapiens)

Coordinate

124

Modification

K63polyUb [endosome membrane]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_033450.2, NP_001290202.1

ENSEMBL

ENSMUSG00000027164, ENSMUSP00000004949, ENSMUST00000004949

PRO

P70196

MGI

108072

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62991 UBIQ			0.835	5
UniProt:Q9QZH6	2	Ecsit [mitochondrial inner membrane] (R-MMU-5689047) Ecsit [cytosol] (R-MMU-168064)	0.729	5
UniProt:P22366	1	Myd88 [cytosol] (R-MMU-166059)	0.623	4
UniProt:Q61084	1	MAP3K3 [cytosol] (R-MMU-507725)	0.589	5
UniProt:Q8C0E5 Q8C0E5			0.581	3
UniProt:Q8K4B2	1	IRAK3 [cytosol] (R-MMU-166103)	0.547	3
UniProt:Q8N7N6 CIKS			0.547	4
UniProt:Q62227	1	Nr0b2 [nucleoplasm] (R-MMU-376312)	0.537	5
UniProt:P17879	4	HSPA1A [extracellular region] (R-MMU-6805872) HSPA1A [ficolin-1-rich granule lumen] (R-MMU-6801496) HSPA1A [cytosol] (R-MMU-6792602) HSPA1A [nucleoplasm] (R-MMU-6792605)	0.524	3
UniProt:Q9EQY0	2	phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (R-MMU-381029) ERN1 [endoplasmic reticulum membrane] (R-MMU-381076)	0.524	6
UniProt:Q793I8	2	Tifa [cytosol] (R-MMU-451582) phospho-Tifa [cytosol] (R-MMU-9645512)	0.508	2
UniProt:O35305	1	TNFRSF11A [plasma membrane] (R-MMU-5668756)	0.508	2
UniProt:P27512	1	Cd40 [plasma membrane] (R-MMU-198117)	0.508	2
UniProt:Q96CG3 TIFA	2	TIFA [cytosol] (R-HSA-451582) p-T9-TIFA [cytosol] (R-HSA-9645512)	0.499	4