Reactome | phospho-Tifa [cytosol]

phospho-Tifa [cytosol]

Stable Identifier

R-MMU-9645512

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

p-T9-TIFA, Q793I8

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-1 family signaling (Mus musculus)
      - Interleukin-1 signaling (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
- Innate Immune System (Mus musculus)
  - Alpha-protein kinase 1 signaling pathway (Mus musculus)
    - ALPK1 phosphorylates TIFA (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA dimer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
    - ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
    - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
    - Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
    - Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
    - Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
    - TIFA oligomerization (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA dimer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
    - TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
    - Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
    - Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
      - TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
    - Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
      - MyD88-independent TLR4 cascade (Mus musculus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
    - Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)
    - Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Mus musculus)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)
        
        phospho-Tifa [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q793I8

Gene Names

Tifa

Reference Genes

BioGPS Gene:211550 Tifa

ENSEMBL:ENSMUSG00000046688

KEGG:mmu:211550 Tifa

Monarch:211550 Tifa

NCBI Gene:211550 Tifa

UCSC:Q793I8 Tifa

Reference Transcript

Other Identifiers

10495967

113248_at

1426501_a_at

17402519

211550

4462531

4484513

4531420

4628430

4865474

4908180

4913887

5090438

5280272

5283314

5325325

5459878

5494203

A_51_P249989

A_55_P2011385

GE130657

GO:0002376

GO:0002753

GO:0005515

GO:0005737

GO:0033209

GO:0043123

GO:0045087

GO:0051260

GO:0065003

GO:0098542

ILMN_1233896

mMC018951

Participates

as a component of

p-T9-TIFA:p-T9-TIFA [cytosol] (Mus musculus)

Other forms of this molecule

Tifa [cytosol]

Inferred From

p-T9-TIFA [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 9 (in Homo sapiens)

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001343359.1, NP_660115.1, XP_006501301.1, XP_006501300.1

ENSEMBL

ENSMUST00000163775, ENSMUSP00000126692, ENSMUSG00000046688, ENSMUST00000054483, ENSMUST00000171621, ENSMUSP00000054036, ENSMUSP00000132309, ENSMUSP00000127700, ENSMUST00000164447

PRO

Q793I8

MGI

2182965

PDB

6L9W, 6L9U, 6L9V, 8WWY

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q62406 Irak1	9	Irak1 [cytosol] (R-MMU-9027461) phospho-K63polyUb-hp-IRAK1 [endosome membrane] (R-MMU-975112) phospho-p-S,T-IRAK1 [cytosol] (R-MMU-3149574) phospho-p-S376,T387-IRAK1 [cytosol] (R-MMU-446687) phospho-K63polyUb-hp-IRAK1 [cytosol] (R-MMU-451565) phospho-p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-MMU-975157) phospho-p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-MMU-937011) phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-MMU-446682) IRAK1 [cytosol] (R-MMU-446639)	0.524	2
UniProt:P70196 Traf6	1	Traf6 [cytosol] (R-MMU-933459)	0.508	2

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