Reactome | Traf6 [cytosol]

Traf6 [cytosol]

Stable Identifier

R-MMU-2685681

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

K63polyUb-TRAF6, P70196

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - TCR signaling (Mus musculus)
    - Downstream TCR signaling (Mus musculus)
      - Activation of IKK complex (Mus musculus)
        
        TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Mus musculus)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - Activation of TAK1-TAB2 complex (Mus musculus)
        
        TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Mus musculus)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - Auto-ubiquitination of TRAF6 (Mus musculus)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - Ubiquitination of NEMO by TRAF6 (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-1 family signaling (Mus musculus)
      - Interleukin-1 signaling (Mus musculus)
        
        Polyubiquitinated TRAF6 binds the TAK1 complex (Mus musculus)
        
        hp-IRAK1:3xK63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K6-poly-Ub oligo-TRAF6:TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        TAK1 is activated within the TAK1 complex (Mus musculus)
        
        hp-IRAK1:K6-poly-Ub oligo-TRAF6:TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        TRAF6 is K63 poly-ubiquitinated (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
    - Interleukin-17 signaling (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
- Innate Immune System (Mus musculus)
  - Alpha-protein kinase 1 signaling pathway (Mus musculus)
    - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
    - Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - Traf6 [cytosol] (Mus musculus)
    - Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
    - Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Mus musculus)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
  - C-type lectin receptors (CLRs) (Mus musculus)
    - CLEC7A (Dectin-1) signaling (Mus musculus)
      - K63polyUb-TAK1 autophosphorylates (Mus musculus)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-TAK1 [plasma membrane] (Mus musculus)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Mus musculus)
        
        K63polyUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane] (Mus musculus)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Mus musculus)
        
        K63polyUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - K63polyUb-TRAF6 ubiquitinates TAK1 (Mus musculus)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-TAK1 [plasma membrane] (Mus musculus)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Mus musculus)
        
        K63polyUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane] (Mus musculus)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Mus musculus)
        
        K63polyUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Mus musculus)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane] (Mus musculus)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Mus musculus)
        
        K63polyUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - TRAF6 oligomer autoubiquitinates (Mus musculus)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Mus musculus)
        
        K63polyUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - TRIKA2 binds K63polyUb-TRAF6 oligomer (Mus musculus)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Mus musculus)
        
        K63polyUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane] (Mus musculus)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Mus musculus)
        
        K63polyUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - Ubiquitination of NEMO by TRAF6 (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
  - Fc epsilon receptor (FCERI) signaling (Mus musculus)
    - FCERI mediated NF-kB activation (Mus musculus)
      - Activation of TAK1 complex bound to pUb-TRAF6 (Mus musculus)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Mus musculus)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Mus musculus)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - Auto-ubiquitination of TRAF6 (Mus musculus)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Mus musculus)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - Phosphorylation of IKK-beta by TAK1 (Mus musculus)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Mus musculus)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Mus musculus)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Mus musculus)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Mus musculus)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Mus musculus)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Mus musculus)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - Ubiquitination of NEMO by TRAF6 (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
    - Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
    - Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
    - Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
      - MyD88-independent TLR4 cascade (Mus musculus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        TRAF6-mediated induction of TAK1 complex within TLR4 complex (Mus musculus)
        
        Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Mus musculus)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Mus musculus)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Mus musculus)
        
        K63-linked polyUb TRAF6 complexes [endosome membrane] (Mus musculus)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Activation of TAK1 complex bound to activated TLR4 complex (Mus musculus)
        
        activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Mus musculus)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Mus musculus)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Mus musculus)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Phosphorylated TAK1 leaves activated TLR receptor complex (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Mus musculus)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
    - Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Mus musculus)
        
        Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Mus musculus)
        
        K63-linked polyUb TRAF6 complexes [endosome membrane] (Mus musculus)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
    - Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Mus musculus)
        
        Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Mus musculus)
        
        K63-linked polyUb TRAF6 complexes [endosome membrane] (Mus musculus)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        Activated TAK complexes [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Ubiquitination of IKBKG by TRAF6 (Mus musculus)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Mus musculus)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Mus musculus)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Mus musculus)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Death Receptor Signaling (Mus musculus)
  - p75 NTR receptor-mediated signalling (Mus musculus)
    - p75NTR signals via NF-kB (Mus musculus)
      - p75NTR recruits signalling complexes (Mus musculus)
        
        TRAF6 is auto-ubiquitinated (Mus musculus)
        
        NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Mus musculus)
        
        Traf6 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P70196 Traf6

Gene Names

Traf6

Chain

chain:1-530

Reference Genes

BioGPS Gene:22034 Traf6

KEGG:mmu:22034 Traf6

Monarch:22034 Traf6

NCBI Gene:22034 Traf6

UCSC:P70196 Traf6

Reference Transcript

Participates

as a component of

as a member of

K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Mus musculus)

as a repeated unit of

K63polyUb-TRAF6 oligomer [cytosol] (Mus musculus)

Other forms of this molecule

Traf6 [cytosol]

Traf6 [endosome membrane]

Traf6 [plasma membrane]

Traf6 [cytosol]

Inferred From

K63polyUb-TRAF6 [cytosol] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 124 (in Homo sapiens)

Coordinate

124

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_033450.2, NP_001290202.1

ENSEMBL

ENSMUSG00000027164, ENSMUST00000004949, ENSMUSP00000004949

PRO

P70196

MGI

108072

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62991 UBIQ			0.835	5
UniProt:Q9QZH6	2	Ecsit [mitochondrial inner membrane] (R-MMU-5689047) Ecsit [cytosol] (R-MMU-168064)	0.729	5
UniProt:P22366	1	Myd88 [cytosol] (R-MMU-166059)	0.623	4
UniProt:Q61084	1	MAP3K3 [cytosol] (R-MMU-507725)	0.589	5
UniProt:Q8C0E5 Q8C0E5			0.581	3
UniProt:Q8K4B2	1	IRAK3 [cytosol] (R-MMU-166103)	0.547	3
UniProt:Q8N7N6 CIKS			0.547	4
UniProt:Q62227	1	Nr0b2 [nucleoplasm] (R-MMU-376312)	0.537	5
UniProt:P17879	4	HSPA1A [nucleoplasm] (R-MMU-6792605) HSPA1A [extracellular region] (R-MMU-6805872) HSPA1A [ficolin-1-rich granule lumen] (R-MMU-6801496) HSPA1A [cytosol] (R-MMU-6792602)	0.524	3
UniProt:Q9EQY0	2	phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (R-MMU-381029) ERN1 [endoplasmic reticulum membrane] (R-MMU-381076)	0.524	6
UniProt:Q793I8	2	Tifa [cytosol] (R-MMU-451582) phospho-Tifa [cytosol] (R-MMU-9645512)	0.508	2
UniProt:O35305	1	TNFRSF11A [plasma membrane] (R-MMU-5668756)	0.508	2
UniProt:P27512	1	Cd40 [plasma membrane] (R-MMU-198117)	0.508	2
UniProt:Q96CG3 TIFA	2	TIFA [cytosol] (R-HSA-451582) p-T9-TIFA [cytosol] (R-HSA-9645512)	0.499	4

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