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phospho-pS-172,K48polyUb-TBK1 [cytosol]
Stable Identifier
R-MMU-3249397
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q9WUN2
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Cytosolic sensors of pathogen-associated DNA (Mus musculus)
Regulation of innate immune responses to cytosolic DNA (Mus musculus)
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Mus musculus)
STING:p-S172,K48polyUb-TBK1:IRF3 [cytoplasmic vesicle membrane] (Mus musculus)
phospho-pS-172,K48polyUb-TBK1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9WUN2 Tbk1
Gene Names
Tbk1
Chain
chain:1-729
Reference Genes
BioGPS Gene:56480 Tbk1
KEGG:mmu:56480 Tbk1
Monarch:56480 Tbk1
NCBI Gene:56480 Tbk1
UCSC:Q9WUN2 Tbk1
Reference Transcript
RefSeq:NM_019786.4 Tbk1
Other Identifiers
10372853
1422469_at
1445571_at
1460315_s_at
17245488
4333825
4335136
4345558
4355811
4411969
4448497
4461383
4531251
4551086
4558686
4606948
4674021
4735410
4817256
4860585
4863430
4893102
4895715
4932712
4954614
4981956
5072802
5080532
5083240
5092588
5118097
5161944
5223573
5265233
5308606
5331374
5337742
5419176
5476186
5489518
5513820
56480
98087_at
A_51_P169850
A_52_P532029
GE37612
GO:0000166
GO:0002181
GO:0002218
GO:0002376
GO:0002753
GO:0003676
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006468
GO:0006606
GO:0006886
GO:0006913
GO:0009299
GO:0010468
GO:0010508
GO:0010628
GO:0010629
GO:0016071
GO:0016239
GO:0016301
GO:0016740
GO:0018105
GO:0018107
GO:0019903
GO:0030154
GO:0031669
GO:0032008
GO:0032479
GO:0032481
GO:0032727
GO:0032728
GO:0034142
GO:0038202
GO:0038203
GO:0042802
GO:0043123
GO:0043491
GO:0044565
GO:0045087
GO:0045944
GO:0045948
GO:0050830
GO:0051219
GO:0051607
GO:0051897
GO:0060340
GO:0061470
GO:0061629
GO:0098542
GO:0106310
GO:0140096
GO:0140374
GO:0140896
GO:1904262
GO:1904263
GO:1904417
GO:1904515
ILMN_1241535
mMC018910
Participates
as a component of
STING:p-S172,K48polyUb-TBK1:IRF3 [cytoplasmic vesicle membrane] (Mus musculus)
Other forms of this molecule
phospho-Q9WUN2 [cytosol]
K63polyUb-K30,K401-TBK1 [cytosol]
Tbk1 [cytosol]
p-S172-Tbk1 [cytosol]
Inferred From
pS-172,K48polyUb-TBK1 [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 670 (in Homo sapiens)
Coordinate
670
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
O-phospho-L-serine at 172
Coordinate
172
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_062760.3
ENSEMBL
ENSMUSG00000020115
,
ENSMUSP00000020316
,
ENSMUST00000020316
ZINC - Substances
TBK1_MOUSE
ZINC target
Q9WUN2
PRO
Q9WUN2
MGI
1929658
ZINC - Predictions - Purchasable
TBK1_MOUSE
PDB
4JL9
,
6O8C
,
4JLC
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P70347
2
K63polyUb-TANK [cytosol]
(R-MMU-5362480)
TANK [cytosol]
(R-MMU-933407)
0.75
7
UniProt:Q9WUN2 Tbk1
5
phospho-pS-172,K48polyUb-TBK1 [cytosol]
(R-MMU-3249397)
phospho-Q9WUN2 [cytosol]
(R-MMU-9008705)
K63polyUb-K30,K401-TBK1 [cytosol]
(R-MMU-9730430)
Tbk1 [cytosol]
(R-MMU-1810477)
p-S172-Tbk1 [cytosol]
(R-MMU-1810465)
0.719
5
UniProt:Q80UF7
1
Ticam1 [cytosol]
(R-MMU-166170)
0.589
2
UniProt:Q3TBT3
5
TMEM173 [plasma membrane]
(R-MMU-6804815)
TMEM173 [secretory granule membrane]
(R-MMU-6804798)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-MMU-3134805)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-MMU-3248021)
STING [endoplasmic reticulum membrane]
(R-MMU-1834940)
0.564
3
UniProt:A2A9T0 TBKB1
0.499
2
UniProt:O41932 O41932
0.463
3
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