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Tbk1 [cytosol]
Stable Identifier
R-MMU-1810477
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Autophagy (Mus musculus)
Macroautophagy (Mus musculus)
Selective autophagy (Mus musculus)
Mitophagy (Mus musculus)
PINK1-PRKN Mediated Mitophagy (Mus musculus)
OPTN, TBK1 bind ubiquitinated MOM proteins (Mus musculus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Mus musculus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-37 signaling (Mus musculus)
TBK1 phosphorylation (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
Cytosolic sensors of pathogen-associated DNA (Mus musculus)
STING mediated induction of host immune responses (Mus musculus)
IRF3-mediated induction of type I IFN (Mus musculus)
TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Mus musculus)
STING:TBK1:IRF3 [cytoplasmic vesicle membrane] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
STAT6-mediated induction of chemokines (Mus musculus)
STING recruits TBK1 and STAT6 (Mus musculus)
STING:TBK1:STAT6 [cytoplasmic vesicle membrane] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Mus musculus)
STING:TBK1:STAT6 [cytoplasmic vesicle membrane] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Mus musculus)
HSP90 binds TBK1 and IRF3 (Mus musculus)
HSP90:TBK1:IRF3 [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
Negative regulators of DDX58/IFIH1 signaling (Mus musculus)
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Mus musculus)
TAX1BP1:TNFAIP3:TBK1/IKBKE [cytosol] (Mus musculus)
TBK1, IKBKE [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
TBK1, IKBKE [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Mus musculus)
Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Mus musculus)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
TBK1:TBK1 [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Mus musculus)
OPTN binds TBK1 within the activated TLR4 complex (Mus musculus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Mus musculus)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
TBK1:TBK1 [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
TBK1:TBK1 [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Mus musculus)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
TBK1:TBK1 [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
TBK1 is phosphorylated within the activated TLR4 complex (Mus musculus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Mus musculus)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
TBK1:TBK1 [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
TBK1:TBK1 [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Mus musculus)
TBK1, IKBKE [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9WUN2 Tbk1
Gene Names
Tbk1
Chain
chain:1-729
Reference Genes
BioGPS Gene:56480 Tbk1
KEGG:mmu:56480 Tbk1
Monarch:56480 Tbk1
NCBI Gene:56480 Tbk1
UCSC:Q9WUN2 Tbk1
Reference Transcript
RefSeq:NM_019786.4 Tbk1
Other Identifiers
10372853
1422469_at
1445571_at
1460315_s_at
17245488
4333825
4335136
4345558
4355811
4411969
4448497
4461383
4531251
4551086
4558686
4606948
4674021
4735410
4817256
4860585
4863430
4893102
4895715
4932712
4954614
4981956
5072802
5080532
5083240
5092588
5118097
5161944
5223573
5265233
5308606
5331374
5337742
5419176
5476186
5489518
5513820
56480
98087_at
A_51_P169850
A_52_P532029
GE37612
GO:0002218
GO:0002376
GO:0002753
GO:0003676
GO:0003824
GO:0004672
GO:0004674
GO:0004676
GO:0004677
GO:0004679
GO:0004694
GO:0004711
GO:0005515
GO:0005524
GO:0005654
GO:0005737
GO:0005829
GO:0006325
GO:0006338
GO:0006355
GO:0006468
GO:0010468
GO:0010508
GO:0010628
GO:0010629
GO:0016239
GO:0016740
GO:0018105
GO:0018107
GO:0019222
GO:0019903
GO:0030154
GO:0032479
GO:0032481
GO:0032727
GO:0032728
GO:0034142
GO:0035175
GO:0035402
GO:0035403
GO:0035979
GO:0042802
GO:0043123
GO:0043226
GO:0043231
GO:0044022
GO:0044023
GO:0044024
GO:0044025
GO:0044565
GO:0045087
GO:0045944
GO:0050830
GO:0051219
GO:0051607
GO:0060340
GO:0061470
GO:0072354
GO:0072371
GO:0072518
GO:0098542
GO:0106310
GO:0140096
GO:0140374
GO:0140823
GO:0140855
GO:0140857
GO:1904262
GO:1904263
GO:1904417
GO:1904515
GO:1990244
ILMN_1241535
mMC018910
Participates
as an input of
STING recruits TBK1 and STAT6 (Mus musculus)
Recruitment Tbk1 to dsDNA:Dai followed by its activation (Mus musculus)
TBK1 phosphorylation (Mus musculus)
Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Mus musculus)
HSP90 binds TBK1 and IRF3 (Mus musculus)
OPTN, TBK1 bind ubiquitinated MOM proteins (Mus musculus)
as a component of
STING:TBK1:STAT6 [cytoplasmic vesicle membrane] (Mus musculus)
STING:TBK1:IRF3 [cytoplasmic vesicle membrane] (Mus musculus)
TBK1:TBK1 [cytosol] (Mus musculus)
HSP90:TBK1:IRF3 [cytosol] (Mus musculus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Mus musculus)
as a member of
TBK1, IKBKE [cytosol] (Mus musculus)
Other forms of this molecule
phospho-Tbk1 [cytosol]
phospho-Tbk1 [cytosol]
Tbk1 [cytosol]
p-S172-Tbk1 [cytosol]
Inferred From
TBK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_062760.3
ENSEMBL
ENSMUSG00000020115
,
ENSMUST00000020316
,
ENSMUSP00000020316
ZINC - Substances
TBK1_MOUSE
ZINC target
Q9WUN2
PRO
Q9WUN2
MGI
1929658
ZINC - Predictions - Purchasable
TBK1_MOUSE
PDB
4JLC
,
6O8C
,
4JL9
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P70347
2
Tank [cytosol]
(R-MMU-5362480)
Tank [cytosol]
(R-MMU-933407)
0.75
7
UniProt:Q9WUN2 Tbk1
5
phospho-Tbk1 [cytosol]
(R-MMU-3249397)
phospho-Tbk1 [cytosol]
(R-MMU-9008705)
Tbk1 [cytosol]
(R-MMU-9730430)
Tbk1 [cytosol]
(R-MMU-1810477)
p-S172-Tbk1 [cytosol]
(R-MMU-1810465)
0.719
5
UniProt:Q80UF7
1
Ticam1 [cytosol]
(R-MMU-166170)
0.589
2
UniProt:Q3TBT3
5
Sting1 [endoplasmic reticulum membrane]
(R-MMU-3134805)
Sting1 [cytoplasmic vesicle membrane]
(R-MMU-3248021)
Sting1 [plasma membrane]
(R-MMU-6804815)
Sting1 [secretory granule membrane]
(R-MMU-6804798)
Sting1 [endoplasmic reticulum membrane]
(R-MMU-1834940)
0.564
3
UniProt:A2A9T0 TBKB1
0.499
2
UniProt:O41932 O41932
0.463
3
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