Recruitment Tbk1 to dsDNA:Dai followed by its activation

Stable Identifier
R-MMU-1810473
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Recruitment Tbk1 to dsDNA:Dai followed by its activation
In murine L929 cells Dai dimer formation enables recruitment of Tbk1 and Irf3 to the C-terminal region of Dai in response to cytosolic DNA. This interaction is DNA-dependent as Dai mutants that lack DNA binding domains neither recruited Tbk1 nor activated Irf3 (Takaoka A et al 2007).
Literature References
PubMed ID Title Journal Year
17618271 DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

Lu, Y, Choi, MK, Ohba, Y, Ban, T, Miyagishi, M, Yanai, H, Honda, K, Wang, Z, Takaoka, A, Taniguchi, T, Kodama, T, Negishi, H

Nature 2007
Participants
Input
Output
Orthologous Events
Recruitment TBK1 to dsDNA:ZBP1 followed by its activation (Homo sapiens)
Authored
Shamovsky, V  (2011-09-21)
Reviewed
Mocarski, ES  (2012-02-19)
Upton, JW  (2012-02-19)
D'Eustachio, P  (2011-12-08)
Created
Shamovsky, V  (2011-10-25)
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