Reactome | Cd4 [plasma membrane]

Cd4 [plasma membrane]

Stable Identifier

R-MMU-167542

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

CD4, P06332

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd4 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd4 [plasma membrane] (Mus musculus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
      - CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd4 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd4 [plasma membrane] (Mus musculus)
    - Cargo recognition for clathrin-mediated endocytosis (Mus musculus)
      - AP-2 directly binds some endocytic cargo (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd4 [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd4 [plasma membrane] (Mus musculus)
    - Clathrin recruits PIK3C2A (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd4 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd4 [plasma membrane] (Mus musculus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd4 [plasma membrane] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd4 [plasma membrane] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd4 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd4 [plasma membrane] (Mus musculus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd4 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd4 [plasma membrane] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd4 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd4 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P06332

Gene Names

Cd4

Reference Genes

BioGPS Gene:12504 Cd4

ENSEMBL:ENSMUSG00000023274

ENSEMBL:ENSMUSG00000023274.15 Cd4

KEGG Gene (Mus musculus):12504 Cd4

Monarch:12504 Cd4

NCBI Gene:12504 Cd4

UCSC:P06332 Cd4

Reference Transcript

RefSeq:NM_013488.2 Cd4

Other Identifiers

103480_at

10547894

12504

1419696_at

1427779_a_at

17470960

4667208

4712532

4728550

4886467

4919568

4953193

5002436

5021946

5035984

5124271

5206866

5316597

5510288

5573471

A_52_P383089

A_55_P2013655

GE36571

GO:0001934

GO:0002250

GO:0002376

GO:0005102

GO:0005515

GO:0005783

GO:0005788

GO:0005789

GO:0005886

GO:0006351

GO:0006355

GO:0006955

GO:0007155

GO:0007166

GO:0008270

GO:0008289

GO:0009897

GO:0009986

GO:0010524

GO:0015026

GO:0016020

GO:0019722

GO:0019865

GO:0019899

GO:0019901

GO:0023026

GO:0023052

GO:0030154

GO:0030217

GO:0030225

GO:0032507

GO:0035397

GO:0035723

GO:0036211

GO:0042011

GO:0042012

GO:0042102

GO:0042110

GO:0042289

GO:0042802

GO:0042803

GO:0043123

GO:0043226

GO:0043410

GO:0045058

GO:0045121

GO:0045657

GO:0045893

GO:0046598

GO:0048856

GO:0050731

GO:0050829

GO:0050850

GO:0050863

GO:0050870

GO:0051924

GO:0055085

GO:0060089

GO:0070374

GO:0097011

GO:0098542

GO:1990782

ILMN_1249663

mMC002333

x04836_s_at

Participates

as a member of

AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)

as an input of

as a component of

Other forms of this molecule

Cd4 [clathrin-coated endocytic vesicle membrane]

Inferred From

CD4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_038516.1

Ensembl

ENSMUSP00000024044, ENSMUST00000024044, ENSMUSG00000023274

PRO

P06332

MGI

88335

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06240 Lck	5	phospho-p-Y394-LCK [plasma membrane] (R-MMU-8857940) Lck [cytosol] (R-MMU-539041) phospho-p-Y505-LCK [plasma membrane] (R-MMU-202159) phospho-p-Y394-LCK [cytosol] (R-MMU-202308) LCK [cytosol] (R-MMU-167609)	0.681	3

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