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phospho-p-Y505-LCK [plasma membrane]
Stable Identifier
R-MMU-202159
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
P06240
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
TCR signaling (Mus musculus)
Phosphorylation of CD3 and TCR zeta chains (Mus musculus)
Dephosphorylation of Lck-pY505 by CD45 (Mus musculus)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Mus musculus)
phospho-p-Y505-LCK [plasma membrane] (Mus musculus)
Inactivation of Lck by Csk (Mus musculus)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Mus musculus)
phospho-p-Y505-LCK [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:P06240 Lck
Gene Names
Lck, Lsk-t
Chain
initiator methionine:, chain:2-509
Reference Genes
BioGPS Gene:16818 Lck
KEGG:mmu:16818 Lck
Monarch:16818 Lck
NCBI Gene:16818 Lck
UCSC:P06240 Lck
Reference Transcript
RefSeq:NM_001162433.1 Lck
RefSeq:NM_010693.3 Lck
RefSeq:XM_006502818.3 Lck
Other Identifiers
102809_s_at
10516620
1425396_a_at
1439145_at
1439146_s_at
16818
17430413
4365171
4400266
4406208
4558922
4568065
4636803
4671941
4683421
4695333
4810598
4814668
4988917
5150457
5186492
5290956
5293679
5343788
5394055
5394720
5400253
5463215
5549197
5565059
A_51_P141288
A_55_P2506985
GE112706
GE1466813
GO:0000242
GO:0001772
GO:0001784
GO:0002376
GO:0003823
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0004722
GO:0005102
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0006468
GO:0006882
GO:0006919
GO:0007166
GO:0007169
GO:0009410
GO:0009612
GO:0010038
GO:0010628
GO:0016004
GO:0016740
GO:0016787
GO:0019901
GO:0019903
GO:0030139
GO:0030154
GO:0030217
GO:0031410
GO:0034116
GO:0035556
GO:0038094
GO:0042110
GO:0042169
GO:0042492
GO:0042531
GO:0042542
GO:0042608
GO:0042609
GO:0042610
GO:0042802
GO:0043226
GO:0043274
GO:0043548
GO:0044877
GO:0045087
GO:0045121
GO:0045588
GO:0045589
GO:0050852
GO:0050853
GO:0050856
GO:0050870
GO:0051117
GO:0051209
GO:0055085
GO:0070474
GO:0098542
GO:0098772
GO:0098978
GO:0099091
GO:0140096
GO:0160162
GO:1903039
GO:1990405
GO:2001244
ILMN_1224526
ILMN_2651137
mMC001127
x03533_s_at
Participates
as a component of
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Mus musculus)
Other forms of this molecule
phospho-p-Y394-LCK [plasma membrane]
Lck [cytosol]
phospho-p-Y394-LCK [cytosol]
LCK [cytosol]
Inferred From
p-Y505-LCK [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 505 (in Homo sapiens)
Coordinate
505
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_006502881.1
,
NP_001155905.1
,
NP_034823.1
ZINC - Investigational
LCK_MOUSE
ZINC - World Drugs
LCK_MOUSE
ENSEMBL
ENSMUSP00000099656
,
ENSMUSP00000066209
,
ENSMUST00000067240
,
ENSMUST00000102596
IntEnz
2.7.10.2
ZINC - FDA approved
LCK_MOUSE
ZINC - Substances
LCK_MOUSE
ZINC target
P06240
PRO
P06240
MGI
96756
ZINC - Predictions - Purchasable
LCK_MOUSE
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49710 HCLS1
0.704
6
UniProt:P06332
2
Cd4 [clathrin-coated endocytic vesicle membrane]
(R-MMU-8869082)
Cd4 [plasma membrane]
(R-MMU-167542)
0.681
3
UniProt:P27958 POLG
1
POLG [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HCV-8854138)
0.656
3
UniProt:P06800
2
PTPRC [secretory granule membrane]
(R-MMU-6806150)
PTPRC [plasma membrane]
(R-MMU-197931)
0.59
2
UniProt:O92972 POLG
0.589
2
UniProt:P01731
1
Cd8a [plasma membrane]
(R-MMU-197601)
0.573
2
UniProt:Q63767
4
phospho-Bcar1 [cytosol]
(R-RNO-372645)
phospho-Bcar1 [cytosol]
(R-RNO-5218739)
phospho-Bcar1 [cytosol]
(R-RNO-8848723)
Bcar1 [cytosol]
(R-RNO-201625)
0.558
2
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL [cytosol]
(R-HSA-112199)
p-Y371-CBL [cytosol]
(R-HSA-182940)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
0.524
2
UniProt:Q9QXK9
1
Sh2d2a [cytosol]
(R-MMU-4420125)
0.508
3
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