Reactome | Lck [cytosol]

Lck [cytosol]

Stable Identifier

R-MMU-539041

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Proto-oncogene tyrosine-protein kinase LCK, LCK_MOUSE, Lck

External Reference Information

External Reference

UniProt:P06240 Lck

Gene Names

Lck, Lsk-t

Chain

initiator methionine:1, chain:2-509

Reference Genes

BioGPS Gene:16818 Lck

KEGG Gene (Mus musculus):16818 Lck

Monarch:16818 Lck

NCBI Gene:16818 Lck

UCSC:P06240 Lck

Reference Transcript

Other Identifiers

102809_s_at

10516620

1425396_a_at

1439146_s_at

16818

17430413

4365171

4400266

4406208

4558922

4568065

4636803

4683421

4810598

4988917

5290956

5293679

5343788

5394055

5400253

5549197

5565059

A_51_P141288

GE112706

GO:0000166

GO:0000242

GO:0001772

GO:0001784

GO:0002376

GO:0003012

GO:0003674

GO:0003823

GO:0004672

GO:0004712

GO:0004713

GO:0004715

GO:0004722

GO:0005102

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0006468

GO:0006882

GO:0006919

GO:0007155

GO:0007166

GO:0007169

GO:0008022

GO:0008150

GO:0009410

GO:0009612

GO:0010038

GO:0010628

GO:0012501

GO:0016004

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0016791

GO:0018108

GO:0019899

GO:0019901

GO:0019903

GO:0023052

GO:0030139

GO:0030154

GO:0030217

GO:0030234

GO:0031234

GO:0031410

GO:0034116

GO:0035556

GO:0036211

GO:0038083

GO:0038094

GO:0042169

GO:0042492

GO:0042531

GO:0042542

GO:0042608

GO:0042609

GO:0042610

GO:0042802

GO:0043167

GO:0043226

GO:0043274

GO:0043548

GO:0044877

GO:0045087

GO:0045121

GO:0045588

GO:0045589

GO:0046777

GO:0048856

GO:0050853

GO:0050856

GO:0050870

GO:0051117

GO:0051209

GO:0055065

GO:0055085

GO:0070474

GO:0098542

GO:0098978

GO:0099091

GO:1903039

GO:1990405

GO:2001244

ILMN_1224526

ILMN_2651137

mMC001127

x03533_s_at

Participates

as a member of

Other forms of this molecule

phospho-p-Y394-LCK [plasma membrane]

phospho-p-Y505-LCK [plasma membrane]

phospho-p-Y394-LCK [cytosol]

LCK [cytosol]

Cross References

ZINC - Investigational

LCK_MOUSE

RefSeq

XP_006502881.1, NP_034823.1, NP_001155905.1

ZINC - World Drugs

LCK_MOUSE

IntEnz

2.7.10.2

ZINC - FDA approved

LCK_MOUSE

ZINC - Substances

LCK_MOUSE

Ensembl

ENSMUSP00000099656, ENSMUST00000067240, ENSMUSP00000066209, ENSMUSG00000000409, ENSMUST00000102596

ZINC target

P06240

PRO

P06240

MGI

96756

ZINC - Predictions - Purchasable

LCK_MOUSE

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49710 HCLS1			0.704	6
UniProt:P06332	2	Cd4 [clathrin-coated endocytic vesicle membrane] (R-MMU-8869082) Cd4 [plasma membrane] (R-MMU-167542)	0.681	3
UniProt:P27958 Genome polyprotein	1	POLG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HCV-8854138)	0.656	3
UniProt:P06800	2	PTPRC [secretory granule membrane] (R-MMU-6806150) PTPRC [plasma membrane] (R-MMU-197931)	0.59	2
UniProt:O92972 POLG			0.589	2
UniProt:P01731	1	Cd8a [plasma membrane] (R-MMU-197601)	0.573	2
UniProt:Q63767	4	phospho-Bcar1 [cytosol] (R-RNO-372645) phospho-Bcar1 [cytosol] (R-RNO-5218739) phospho-Bcar1 [cytosol] (R-RNO-8848723) Bcar1 [cytosol] (R-RNO-201625)	0.558	2
UniProt:P22681 CBL	20	CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL del366-409 [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637) CBL G375fs*16 [cytosol] (R-HSA-9706211)	0.524	2
UniProt:Q9QXK9	1	Sh2d2a [cytosol] (R-MMU-4420125)	0.508	3