Reactome | Regulation of IFNA/IFNB signaling

Regulation of IFNA/IFNB signaling

Stable Identifier

R-HSA-912694

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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There are several proteins and mechanisms involved in controlling the extent of ligand stimulation of IFNA/B signaling. These mechanisms can effect every step of the IFNA/B cascade. Dephosphorylation of JAK and STAT by SHP protein phosphatases, inhibition of STAT function in the nucleus by protein inhibitors of activated STATs (PIAS) proteins, inhibition of tyrosine kinase activity of JAKs by SOCS as well as inhibition of JAK and IFNAR2 interaction by UBP43 are few of the negative regulation mechanisms in controling type I IFN signaling.

Literature References

PubMed ID	Title	Journal	Year
10526574	Negative regulators of cytokine signal transduction Hilton, DJ	Cell Mol Life Sci	1999
16710296	UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity Malakhova, OA, Kim, KI, Luo, JK, Zou, W, Kumar, KG, Fuchs, SY, Shuai, K, Zhang, DE	EMBO J	2006
16311601	Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity Fenner, JE, Starr, R, Cornish, AL, Zhang, JG, Metcalf, D, Schreiber, RD, Sheehan, K, Hilton, DJ, Alexander, WS, Hertzog, PJ	Nat Immunol	2006