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VCP hexamer [cytosol]
Stable Identifier
R-HSA-5362364
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Homo sapiens)
NPLOC4:UFD1:VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Hh mutants abrogate ligand secretion (Homo sapiens)
Hh mutants are degraded by ERAD (Homo sapiens)
Hh processing variants are recruited to SEL1:SYVN at the ER membrane (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Hh processing variants are translocated to the cytosol in a VCP-dependent manner (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Hh processing variants are ubiquitinated (Homo sapiens)
SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
ABC transporter disorders (Homo sapiens)
Defective CFTR causes cystic fibrosis (Homo sapiens)
CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)
CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
RNF5 and RNF185 ubiquitinate CFTR F508del (Homo sapiens)
CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Dengue Virus Infection (Homo sapiens)
Dengue Virus Genome Translation and Replication (Homo sapiens)
Nascent polyprotein starts folding in ER (Homo sapiens)
NPLOC4:UFD1:VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by PD-1 (Homo sapiens)
Regulation of PD-L1(CD274) expression (Homo sapiens)
Regulation of PD-L1(CD274) Post-translational modification (Homo sapiens)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) (Homo sapiens)
Active transport of ubiquitinated CD274 from ER to cytosol (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Poly-Ub-p-S195-CD274:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
p-S195-CD274:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Ubiquitination of CD274 by ERAD complex (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Poly-Ub-p-S195-CD274:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
p-S195-CD274:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
p-S195-CD274:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
p-S195-CD274 binds ERAD complex (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
p-S195-CD274:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Homo sapiens)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Homo sapiens)
Deglycosylation complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Neddylation (Homo sapiens)
UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Homo sapiens)
NPLOC4:UFD1:VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Translation (Homo sapiens)
Ribosome-associated quality control (Homo sapiens)
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide (Homo sapiens)
ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide (Homo sapiens)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide-Ala [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer (Homo sapiens)
LTN1:NEMF:TCF25:VCP hexamer:K48polyUb-nascent peptide-Ala [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer and NPLOC4:UFD1 bind K48polyubiquitin of LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer extracts K48 polyubiquitinated alanine-tailed nascent peptide from VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide (Homo sapiens)
LTN1:NEMF:TCF25:VCP hexamer:K48polyUb-nascent peptide-Ala [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide-Ala [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog ligand biogenesis (Homo sapiens)
C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Homo sapiens)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
SYVN1 ubiquitinates Hh C-terminal fragments (Homo sapiens)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
ABC-family protein mediated transport (Homo sapiens)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Homo sapiens)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
VCP hexamer [cytosol] (Homo sapiens)
Participants
components
x 6
VCP [cytosol]
(Homo sapiens)
Participates
as an output of
The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer (Homo sapiens)
as a component of
LTN1:NEMF:TCF25:VCP hexamer:K48polyUb-nascent peptide-Ala [cytosol] (Homo sapiens)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide-Ala [cytosol] (Homo sapiens)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
NPLOC4:UFD1:VCP hexamer [cytosol] (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
Deglycosylation complex [endoplasmic reticulum membrane] (Homo sapiens)
as an input of
VCP hexamer and NPLOC4:UFD1 bind K48polyubiquitin of LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide (Homo sapiens)
Inferred To
VCP hexamer [cytosol]
(Bos taurus)
VCP hexamer [cytosol]
(Caenorhabditis elegans)
VCP hexamer [cytosol]
(Canis familiaris)
VCP hexamer [cytosol]
(Danio rerio)
VCP hexamer [cytosol]
(Dictyostelium discoideum)
VCP hexamer [cytosol]
(Drosophila melanogaster)
VCP hexamer [cytosol]
(Gallus gallus)
VCP hexamer [cytosol]
(Mus musculus)
VCP hexamer [cytosol]
(Plasmodium falciparum)
VCP hexamer [cytosol]
(Rattus norvegicus)
VCP hexamer [cytosol]
(Saccharomyces cerevisiae)
VCP hexamer [cytosol]
(Schizosaccharomyces pombe)
VCP hexamer [cytosol]
(Sus scrofa)
VCP hexamer [cytosol]
(Xenopus tropicalis)
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