Reactome | Formation of the canonical BAF (cBAF) complex

Formation of the canonical BAF (cBAF) complex

Stable Identifier

R-HSA-9933937

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Formation of the canonical BAF (cBAF) complex

Click the image above or here to open this pathway in the Pathway Browser

The mammalian canonical BRG1-associated factors (BAF) complex is the paralog of the budding yeast SWI/SNF complex. cBAF is smaller and more abundant than the related polybromo-associated BAF (pBAF) complex. Shared between the two complexes are proteins (or members of protein families) that make up the core of both complexes, including SMARCC and SMARCD proteins, the catalytic subunits SMARCA4 (BRG1) or SMARCA2 (BRM), ACTB, ACTL6A/B and BCL7A/B/C (Wang, Cote et al, 1996; Wang, Xue et al, 1996; Mashtalir et al, 2018; Mashtalir et al, 2020; He et al, 2020; reviewed in Mittal and Robert2, 2020; Cenik and Shilatifard, 2021; Wang and Tang, 2023). Distinguishing components of the cBAF complex include ARID1A or ARID1B, and DPF1/2/3, and SS18 or SS18L1 (shared with ncBAF, described below) (reviewed in Mittal and Roberts, 2020; Cenik and Shilatifard, 2021; Innis and Cabot; 2020; Wang and Tang, 2023).
Mammalian cBAF complexes are required for chromatin remodelling and oppose polycomb repression (Kadoch et al, 2017; Stanton et al, 2017; Wilson et al, 2010). Unlike in yeast, however, mammalian cBAF complexes are able to support both gene activation and repression (Boyer et al, 2005; Ho et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
37031881	SWI/SNF complexes and cancers Wang, L, Tang, J	Gene	2023
16153702	Core transcriptional regulatory circuitry in human embryonic stem cells Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA	Cell	2005
20951942	Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation Wilson, BG, Wang, X, Shen, X, McKenna, ES, Lemieux, ME, Cho, YJ, Koellhoffer, EC, Pomeroy, SL, Orkin, SH, Roberts, CW	Cancer Cell	2010
32303701	The SWI/SNF complex in cancer - biology, biomarkers and therapy Mittal, P, Roberts, CWM	Nat Rev Clin Oncol	2020
33053319	A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms Mashtalir, N, Suzuki, H, Farrell, DP, Sankar, A, Luo, J, Filipovski, M, D'Avino, AR, St Pierre, R, Valencia, AM, Onikubo, T, Roeder, RG, Han, Y, He, Y, Ranish, JA, Dimaio, F, Walz, T, Kadoch, C	Cell	2020
32001526	Structure of nucleosome-bound human BAF complex He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y	Science	2020
8895581	Purification and biochemical heterogeneity of the mammalian SWI-SNF complex Wang, W, Côté, J, Xue, Y, Zhou, S, Khavari, PA, Biggar, SR, Muchardt, C, Kalpana, GV, Goff, SP, Yaniv, M, Workman, JL, Crabtree, GR	EMBO J.	1996
27941796	Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states Kadoch, C, Williams, RT, Calarco, JP, Miller, EL, Weber, CM, Braun, SM, Pulice, JL, Chory, EJ, Crabtree, GR	Nat Genet	2017
32958894	COMPASS and SWI/SNF complexes in development and disease Cenik, BK, Shilatifard, A	Nat Rev Genet	2021
19279218	An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network Ho, L, Jothi, R, Ronan, JL, Cui, K, Zhao, K, Crabtree, GR	Proc Natl Acad Sci U S A	2009
33143733	GBAF, a small BAF sub-complex with big implications: a systematic review Innis, SM, Cabot, B	Epigenetics Chromatin	2020
8804307	Diversity and specialization of mammalian SWI/SNF complexes Wang, W, Xue, Y, Zhou, S, Kuo, A, Cairns, BR, Crabtree, GR	Genes Dev	1996
27941795	Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin Stanton, BZ, Hodges, C, Calarco, JP, Braun, SM, Ku, WL, Kadoch, C, Zhao, K, Crabtree, GR	Nat Genet	2017
30343899	Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes Mashtalir, N, D'Avino, AR, Michel, BC, Luo, J, Pan, J, Otto, JE, Zullow, HJ, McKenzie, ZM, Kubiak, RL, St Pierre, R, Valencia, AM, Poynter, SJ, Cassel, SH, Ranish, JA, Kadoch, C	Cell	2018