Reactome | FOXP2 [nucleoplasm]

FOXP2 [nucleoplasm]

Stable Identifier

R-HSA-9930691

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Forkhead box protein P2

Locations in the PathwayBrowser for interactor UniProt:O15409 FOXP2

Expand all

Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        Positive Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        FOXA2 stimulates CDH1 gene transcription (Homo sapiens)
        
        FOXP2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15409 FOXP2

Gene Names

FOXP2, CAGH44, TNRC10

Chain

chain:1-715

Reference Genes

BioGPS Gene:93986 FOXP2

COSMIC - genes:FOXP2 FOXP2

CTD Gene:93986 FOXP2

dbSNP Gene:93986 FOXP2

ENSEMBL:ENSG00000128573 FOXP2

HGNC:13875 FOXP2

KEGG:hsa:93986 FOXP2

Monarch:93986 FOXP2

NCBI Gene:93986 FOXP2

OMIM:605317 FOXP2

UCSC:O15409 FOXP2

Reference Transcript

Other Identifiers

11738626_a_at

11740634_a_at

11752148_a_at

11753369_a_at

11762546_at

11762955_at

1552902_PM_a_at

1552902_a_at

1555352_PM_at

1555352_at

1555516_PM_at

1555516_at

1555647_PM_a_at

1555647_a_at

1555648_PM_at

1555648_at

1562139_PM_a_at

1562139_a_at

1564876_3p_s_at

1564876_PM_s_at

1564876_s_at

17050455

235201_PM_at

235201_at

243278_PM_at

243278_at

3019794

3019795

3019807

3019808

3019814

3019821

3019822

3019823

3019824

3019827

3019832

3019833

3019834

3019839

3019841

3019847

3019853

3019854

3019855

3019856

3019857

3019858

3019859

3019861

3019862

3019863

3019865

3019868

3019869

3019870

3019871

3019872

3019873

3019879

3019880

3019881

3019882

3019883

3019884

3019889

3019890

3019891

3019892

3019893

3019894

3019895

3019896

3019906

3019912

3019940

3019941

58863_at

62857_at

8135544

85310_at

93986

A_14_P121404

A_14_P131747

A_23_P134542

A_24_P16556

A_24_P16559

A_24_P38316

A_24_P921683

GE649341

GE771702

GE848262

GO:0000122

GO:0000785

GO:0000978

GO:0000981

GO:0001221

GO:0001227

GO:0002053

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0006355

GO:0006357

GO:0007519

GO:0008270

GO:0009791

GO:0010467

GO:0021549

GO:0021702

GO:0021757

GO:0021758

GO:0021987

GO:0030154

GO:0030324

GO:0042297

GO:0042802

GO:0042803

GO:0043010

GO:0043565

GO:0045892

GO:0046872

GO:0048286

GO:0048513

GO:0048745

GO:0048856

GO:0050679

GO:0060013

GO:0060501

GO:0060502

GO:0071625

HMNXSV003016402

HMNXSV003043637

HMNXSV003056624

Hs.11873.0.A1_3p_at

Hs.149057.0.A1_3p_at

Hs2.282787.1.S1_3p_a_at

Hs2.282787.4.S1_3p_at

Hs2.282787.5.S1_3p_a_at

Hs2.282787.6.S1_3p_s_at

Hs2Affx.1.231.S1_3p_at

Hs2Affx.1.342.S1_3p_at

ILMN_1695355

ILMN_2357701

PH_hs_0014553

TC07000713.hg

TC07002531.hg

p26441

p33723

This entity regulates

Positively

FOXA2 stimulates CDH1 gene transcription (Homo sapiens)

Cross References

RefSeq

NP_001166238.1, NP_683696.2, NP_055306.1, NP_683697.2, NP_683698.2, NP_001166237.1

OpenTargets

ENSG00000128573

ENSEMBL

ENSP00000386200, ENST00000350908, ENSP00000367482, ENSP00000265436, ENSP00000515398, ENSP00000515397, ENSP00000489457, ENST00000360232, ENST00000412402, ENSP00000377129, ENSP00000405470, ENST00000408937, ENST00000393489, ENST00000635109, ENST00000703614, ENSP00000385069, ENST00000703613, ENSG00000128573, ENST00000403559, ENST00000393494, ENST00000378237, ENSP00000353367, ENSP00000416825, ENSP00000377132, ENST00000441290

GeneCards

FOXP2

HPA

ENSG00000128573-FOXP2

PRO

O15409

Pharos - Targets

O15409

GlyGen

O15409

Orphanet

FOXP2

PDB

2A07, 2AS5

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H334 FOXP1			0.909	16
UniProt:Q8IVH2 FOXP4			0.775	9
UniProt:Q13363-2 CTBP1			0.764	7
UniProt:O15409 FOXP2	1	FOXP2 [nucleoplasm] (R-HSA-9930691)	0.738	4
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.718	6
UniProt:Q96A04 TSACC			0.718	6
UniProt:P56545 CTBP2	1	CTBP2 [nucleoplasm] (R-HSA-5333990)	0.666	4
IntAct:EBI-983681 ARRE2			0.591	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
UniProt:Q86V42 F124A			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	3
UniProt:P56545-3 CTBP2			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q00526 CDK3			0.556	3
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.553	2
UniProt:Q9BZS1 FOXP3	1	FOXP3 [nucleoplasm] (R-HSA-8865539)	0.527	3