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FOXP3 [nucleoplasm]
Stable Identifier
R-HSA-8865539
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Forkhead box protein P3, IPEX, JM2
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) (Homo sapiens)
CTLA4 gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3:CTLA4 gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 in complex with RUNX1 binds intron 1 of the IL2RA (CD25) gene (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3:IL2RA gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 in complex with RUNX1 binds the CTLA4 gene promoter (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3:CTLA4 gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 in complex with RUNX1 binds to the TNFRSF18 (GITR) gene intron 1 (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3:TNFRSF18 gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
IFNG gene expression is stimulated by RUNX1 and inhibited by FOXP3 (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3:IFNG gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
IL2 gene expression is stimulated by RUNX1 and NFATC2 and repressed by FOXP3 (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3:NFATC2:IL2 gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
IL2RA (CD25) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3:IL2RA gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1 and FOXP3 bind the IFNG gene (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3:IFNG gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1 binds FOXP3 (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1, FOXP3 and NFATC2 bind the IL2 gene promoter (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3:NFATC2:IL2 gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3:TNFRSF18 gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1 regulates transcription of genes involved in WNT signaling (Homo sapiens)
RUNX1 and FOXP3 bind the RSPO3 gene promoter (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3:RSPO3 gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1 and FOXP3 stimulate the RSPO3 gene expression (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3:RSPO3 gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
FOXP3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BZS1 FOXP3
Gene Names
FOXP3, IPEX, JM2
Chain
chain:1-431, chain:1-417, chain:52-417, propeptide:418-431
Reference Genes
BioGPS Gene:50943 FOXP3
COSMIC (genes):FOXP3 FOXP3
CTD Gene:50943 FOXP3
dbSNP Gene:50943 FOXP3
ENSEMBL:ENSG00000049768 FOXP3
ENSEMBL_homo_sapiens_GENE:ENSG00000049768.18 FOXP3
HGNC:6106 FOXP3
KEGG Gene (Homo sapiens):50943 FOXP3
Monarch:50943 FOXP3
NCBI Gene:50943 FOXP3
OMIM:300292 FOXP3
UCSC:Q9BZS1 FOXP3
Reference Transcript
RefSeq:NM_001114377.1 FOXP3
RefSeq:NM_014009.3 FOXP3
Other Identifiers
11730688_a_at
11730689_a_at
17110902
221333_PM_at
221333_at
221334_PM_s_at
221334_s_at
224211_PM_at
224211_at
4008014
4008015
4008016
4008017
4008018
4008019
4008020
4008021
4008023
4008024
4008025
4008026
4008027
4008028
4008029
4008030
4008041
50943
8172631
A_23_P159709
A_33_P3398251
GE503510
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001227
GO:0001228
GO:0001782
GO:0001818
GO:0002262
GO:0002361
GO:0002362
GO:0002376
GO:0002456
GO:0002507
GO:0002513
GO:0002517
GO:0002637
GO:0002666
GO:0002667
GO:0002669
GO:0002677
GO:0002725
GO:0002851
GO:0002870
GO:0003677
GO:0003700
GO:0003714
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006310
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006954
GO:0007155
GO:0008285
GO:0009615
GO:0010467
GO:0010628
GO:0010629
GO:0014045
GO:0023052
GO:0030154
GO:0032088
GO:0032496
GO:0032689
GO:0032693
GO:0032700
GO:0032703
GO:0032713
GO:0032714
GO:0032715
GO:0032720
GO:0032753
GO:0032792
GO:0032831
GO:0032905
GO:0032914
GO:0032991
GO:0033080
GO:0033092
GO:0035035
GO:0035739
GO:0042098
GO:0042110
GO:0042130
GO:0042802
GO:0042803
GO:0042826
GO:0043029
GO:0043226
GO:0043367
GO:0043372
GO:0043433
GO:0043565
GO:0045066
GO:0045591
GO:0045892
GO:0045893
GO:0045944
GO:0046007
GO:0046633
GO:0046642
GO:0046651
GO:0046872
GO:0048289
GO:0048294
GO:0048302
GO:0048856
GO:0050672
GO:0050687
GO:0050728
GO:0050777
GO:0050852
GO:0051059
GO:0051525
GO:0098542
GO:0140110
GO:1901355
GO:1990837
GO:2000320
GO:2000562
HMNXSV003019715
ILMN_1768049
PH_hs_0032294
TC0X001031.hg
g12407640_3p_at
g7661845_3p_a_at
g7661845_3p_x_at
Participates
as an output of
FOXP3 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)
as an input of
RUNX1 binds FOXP3 (Homo sapiens)
as a component of
RUNX1:CBFB:FOXP3 [nucleoplasm] (Homo sapiens)
Inferred To
Foxp3 [nucleoplasm]
(Mus musculus)
Foxp3 [nucleoplasm]
(Rattus norvegicus)
FOXP3 [nucleoplasm]
(Bos taurus)
FOXP3 [nucleoplasm]
(Canis familiaris)
FOXP3 [nucleoplasm]
(Sus scrofa)
FoxP [nucleoplasm]
(Drosophila melanogaster)
fkh-7 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_054728.2
,
NP_001107849.1
OpenTargets
ENSG00000049768
HPA
ENSG00000049768-FOXP3
GeneCards
Q9BZS1
Ensembl
ENST00000376199
,
ENST00000518685
,
ENSP00000451208
,
ENST00000376207
,
ENST00000557224
,
ENSP00000365380
,
ENSP00000428952
,
ENSP00000365372
,
ENSG00000049768
PRO
Q9BZS1
Pharos - Targets
Q9BZS1
Orphanet
16070
PDB
4WK8
,
3QRF
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q93062 RBPMS
0.742
6
UniProt:P86478 PR20E
0.742
5
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.644
7
UniProt:Q8IVH2 FOXP4
0.643
5
UniProt:Q9H334 FOXP1
0.643
4
UniProt:Q15910 EZH2
1
EZH2 [nucleoplasm]
(R-HSA-212298)
0.602
9
UniProt:P86480 PR20D
0.601
4
UniProt:Q8TF47-3 ZFP90
0.581
4
IntAct:EBI-11820565 HSPA1A
0.576
4
UniProt:Q3LI66 KRTAP6-2
1
KRTAP6-2 [cytosol]
(R-HSA-6810261)
0.556
3
UniProt:P86479 PR20C
0.556
4
UniProt:Q8IUC2 KRTAP8-1
1
KRTAP8-1 [cytosol]
(R-HSA-6810288)
0.556
3
UniProt:Q93062-3 RBPMS
0.556
3
UniProt:Q9BYR6 KRTAP3-3
1
KRTAP3-3 [cytosol]
(R-HSA-6809859)
0.556
3
UniProt:P53539 FOSB
1
FOSB [nucleoplasm]
(R-HSA-9009922)
0.556
3
UniProt:IL2 ENSG00000109471
0.527
2
UniProt:O15409 FOXP2
0.527
3
UniProt:Q9NRG4 SMYD2
1
SMYD2 [nucleoplasm]
(R-HSA-3222233)
0.527
2
UniProt:Q9UKT9 IKZF3
0.524
2
UniProt:P35398-4 RORA
0.508
5
UniProt:Q9H0E7 USP44
1
USP44 [nucleoplasm]
(R-HSA-5696942)
0.463
3
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