Reactome | MARK3 phosphorylates MITF-M on S173

MARK3 phosphorylates MITF-M on S173

Stable Identifier

R-HSA-9926483

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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MARK3, also known as C-TAK1, phosphorylates cytosolic MITF-M, promoting the interaction of MITF-M with 14-3-3 proteins that function to retain it in the cytosol. MARK3-dependent phosphorylation is inhibited by treatment of cells with CSF (colony stimulating factor) and RANKL (receptor activator of nuclear factor kappa beta ligand), disrupting the interaction with 14-3-3 dimers and promoting nuclear localization of MITF-M (Bornisz et al, 2006). CSF and RANKL are produced by osteoblasts and are required for osteoclast formation (reviewed in Boyle et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
16822840	Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors Bronisz, A, Sharma, SM, Hu, R, Godlewski, J, Tzivion, G, Mansky, KC, Ostrowski, MC	Mol Biol Cell	2006
12748652	Osteoclast differentiation and activation Boyle, WJ, Simonet, WS, Lacey, DL	Nature	2003