CD274 Transcription

Stable Identifier
R-HSA-9909623
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CD274 Transcription
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The transcriptional regulation of CD274 (PD-L1/programmed death-ligand 1) is crucial in cancer biology, enabling tumor cells to evade immune detection. PD-L1 expression is tightly controlled by various transcription factors and signalling pathways responding to both intrinsic cellular signals and extrinsic environmental perturbations. It is regulated transcriptionally by multiple mechanisms, including epigenetic modifications (EZH2, DNMTs, MLLs) and transcription factors (STAT3, STAT1, IRF1, MYC, HIF, and others) activated by various upstream signalling pathways. The regulation of PD-L1 is a complex interplay of oncogenic signalling pathways, cytokine responses, epigenetic modifications, specific transcription factors, the tumor microenvironment, and non-coding RNAs. This multifaceted regulation finely tunes PD-L1 expression to promote immune evasion in cancer, making it a critical target for cancer immunotherapy (Zhou et al., 2023, Cha et al.,2019, Yamaguchi et al.,2022, Ju et al., 2020).
Literature References
PubMed ID Title Journal Year
32064150 Regulation of PD-L1 expression in cancer and clinical implications in immunotherapy

Ju, X, Zhang, H, Zhou, Z, Wang, Q

Am J Cancer Res 2020
31668929 Mechanisms Controlling PD-L1 Expression in Cancer

Cha, JH, Chan, LC, Li, CW, Hsu, JL, Hung, MC

Mol Cell 2019
35132224 Mechanisms regulating PD-L1 expression in cancers and associated opportunities for novel small-molecule therapeutics

Yamaguchi, H, Hsu, JM, Yang, WH, Hung, MC

Nat Rev Clin Oncol 2022
37228770 PD-L1: expression regulation

Zhou, YJ, Li, G, Wang, J, Liu, M, Wang, Z, Song, Y, Zhang, X, Wang, X

Blood Sci 2023
32504749 PD-1/PD-L1 axis regulation in cancer therapy: The role of long non-coding RNAs and microRNAs

Ashrafizadeh, M, Zarrabi, A, Hushmandi, K, Zarrin, V, Moghadam, ER, Zabolian, A, Tavakol, S, Samarghandian, S, Najafi, M

Life Sci 2020
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
PRC2(EZH2) Core:H3K27me3 Nucleosome:CD274 gene [nucleoplasm] (Homo sapiens)
Active Unit
PRC2 (EZH2) Core [nucleoplasm]
Positively by
Regulator
CTNNB1:CD274 gene [nucleoplasm] (Homo sapiens)
Active Unit
TCF/LEF:CTNNB1 [nucleoplasm]
Regulator
STAT3_dimer:CD274 gene [nucleoplasm] (Homo sapiens)
Active Unit
STAT3 dimer [nucleoplasm]
Regulator
STAT1_dimer:CD274 gene [nucleoplasm] (Homo sapiens)
Active Unit
STAT1 dimer [nucleoplasm]
Regulator
NRF2:CD274 gene [nucleoplasm] (Homo sapiens)
Active Unit
p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm]
Regulator
MYC,MYCN:CD274 gene [nucleoplasm] (Homo sapiens)
Active Unit
MYC,MYCN [nucleoplasm]
Regulator
YAP1:WWNT1:TEADs:CD274 gene [nucleoplasm] (Homo sapiens)
Active Unit
YAP1:TEAD1,TEAD4,(TEAD2,TEAD3) [nucleoplasm]
YAP1:WWNT1:TEADs:CD274 gene [nucleoplasm]
Regulator
HIF1A,EPAS1:CD274 gene [nucleoplasm] (Homo sapiens)
Active Unit
HIF1 [nucleoplasm]
Regulator
IRF1:CD274 gene [nucleoplasm] (Homo sapiens)
Active Unit
IRF1 [nucleoplasm]
Regulator
ATF3:CD274 gene [nucleoplasm] (Homo sapiens)
Active Unit
ATF3 [nucleoplasm]
Regulator
NFKB_Complex:CD274 gene [nucleoplasm] (Homo sapiens)
Active Unit
NFKB_Complex [nucleoplasm]
Regulator
AP-1:CD274 gene [nucleoplasm] (Homo sapiens)
Active Unit
AP-1 [nucleoplasm]
Regulator
BRD4:CD274 gene chromatin [nucleoplasm] (Homo sapiens)
Active Unit
BRD4 [nucleoplasm]
Regulator
MLL1,MLL3_complex:CD274 gene H3K4me3 chromatin [nucleoplasm] (Homo sapiens)
Active Unit
MLL1 complex [nucleoplasm]
Authored
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Tiwari, K  (2024-11-05)
Reviewed
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Created
Tiwari, K  (2024-05-14)
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