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About
What is Reactome ?
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Table of Contents
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COVID-19 Disease Pathways
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Analyse gene expression
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BRD4 [nucleoplasm]
Stable Identifier
R-HSA-9680425
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Bromodomain-containing protein 4, BRD4_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
BRD4 binds fedratinib (Homo sapiens)
BRD4 [nucleoplasm] (Homo sapiens)
BRD4:fedratinib [nucleoplasm] (Homo sapiens)
BRD4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60885 BRD4
Gene Names
BRD4, HUNK1
Chain
chain:1-1362
Reference Genes
BioGPS Gene:23476 BRD4
COSMIC (genes):BRD4 BRD4
CTD Gene:23476 BRD4
dbSNP Gene:23476 BRD4
ENSEMBL:ENSG00000141867 BRD4
ENSEMBL:ENSG00000141867.19 BRD4
HGNC:13575 BRD4
KEGG Gene (Homo sapiens):23476 BRD4
Monarch:23476 BRD4
NCBI Gene:23476 BRD4
OMIM:608749 BRD4
UCSC:O60885 BRD4
Reference Transcript
RefSeq:NM_058243.2 BRD4
RefSeq:NM_014299.2 BRD4
RefSeq:XM_011527856.2 BRD4
RefSeq:NM_001330384.1 BRD4
RefSeq:XM_011527854.1 BRD4
Other Identifiers
11742831_s_at
11743990_at
11754395_a_at
11762424_at
16869814
202102_PM_s_at
202102_s_at
202103_PM_at
202103_at
226052_3p_at
226052_PM_at
226052_at
226054_PM_at
226054_at
23476
238612_PM_at
238612_at
3853194
3853195
3853196
3853197
3853198
3853199
3853200
3853201
3853202
3853203
3853204
3853205
3853206
3853207
3853209
3853210
3853211
3853212
3853213
3853215
3853217
3853218
3853219
3853220
3853221
3853222
3853223
3853224
3853225
3853227
3853228
3853229
3853230
3853231
3853234
3853235
3853236
3853238
3853239
3853240
3853241
3853244
3853249
3853257
3853258
3853259
3853260
3853263
3853271
3853272
3853273
3853278
3853279
3853292
39093_s_at
39094_at
43796_at
65470_at
66608_r_at
8034983
A_23_P425104
A_33_P3373745
A_33_P3373750
GE61545
GE756521
GO:0000083
GO:0000228
GO:0000278
GO:0000794
GO:0000976
GO:0002039
GO:0003677
GO:0003682
GO:0003712
GO:0003713
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006954
GO:0006974
GO:0008353
GO:0010971
GO:0016740
GO:0019899
GO:0023052
GO:0032968
GO:0042393
GO:0043123
GO:0043226
GO:0043922
GO:0045893
GO:0045944
GO:0050727
GO:0060090
GO:0070577
GO:0099122
GO:0106140
GO:0140096
GO:0140110
GO:0140566
GO:2000002
HMNXSV003028062
HMNXSV003056482
Hs.241097.0.S1_3p_at
Hs.278675.0.S1_3p_a_at
Hs.278675.0.S3_3p_at
Hs.296287.0.A1_3p_at
Hs.296287.0.A2_3p_at
Hs.296287.0.A2_3p_x_at
ILMN_1736981
ILMN_1774134
PH_hs_0014300
RNA147497|p0601_imsncRNA314
TC19001252.hg
p8188
Participates
as a component of
BRD4:fedratinib [nucleoplasm] (Homo sapiens)
as an input of
BRD4 binds fedratinib (Homo sapiens)
Cross References
RefSeq
XP_011526158.1
,
XP_011526156.1
,
NP_490597.1
,
NP_055114.1
,
NP_001317313.1
ZINC - World Drugs
BRD4_HUMAN
Guide to Pharmacology - Targets
1945
OpenTargets
ENSG00000141867
ZINC - FDA approved
BRD4_HUMAN
ZINC - Substances
BRD4_HUMAN
ZINC target
O60885
PRO
O60885
PDB
7P6V
,
5TI2
,
6DJC
,
6PRT
,
6CIS
,
5CQT
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4HXL
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6BN7
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6FT4
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6S4B
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6VUB
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6JJ5
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6MH7
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3SVG
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5Z5T
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6YQN
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5A85
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6U6L
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7ZNT
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6G0E
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5Z5V
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2NCZ
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7ZFZ
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6TPY
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6P05
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5OWM
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6VIX
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6UVM
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5CFW
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5S9P
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3U5J
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7JKX
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5U2C
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7ZG2
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6JJ3
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7RJR
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6WVX
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5MKZ
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6LG8
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6VUF
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4Z1S
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7KHL
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6MH1
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6U6K
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4O7A
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5Z8R
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3SVF
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5Z1T
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5F63
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6ZEL
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6FT3
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,
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,
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,
2YEM
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6BNB
,
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,
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,
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,
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2OUO
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,
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,
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,
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,
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,
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,
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,
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6Z7G
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,
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,
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,
4QR3
,
5WMG
,
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,
7M16
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6V1K
,
6TPZ
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,
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,
3ZYU
,
6FO5
,
5ACY
,
6VIZ
,
5S9Q
,
6Q3Y
,
5UVX
,
7RN2
,
4YH4
,
5HQ6
,
2N3K
,
6SAH
,
6LG4
,
4C67
,
3U5K
,
4DON
,
6C7Q
,
7EIK
,
5KU3
,
6G0Q
,
5W55
ZINC - Investigational
BRD4_HUMAN
HPA
ENSG00000141867-BRD4
GeneCards
O60885
Ensembl
ENSP00000506350
,
ENST00000371835
,
ENSP00000353112
,
ENSP00000360901
,
ENST00000263377
,
ENSG00000141867
,
ENST00000360016
,
ENSP00000263377
,
ENST00000679869
Pharos - Targets
O60885
ZINC - Predictions - Purchasable
BRD4_HUMAN
Orphanet
23630
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04206 RELA
6
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.811
8
UniProt:P03120 VE2
0.765
5
UniProt:Q6NYC1 JMJD6
1
JMJD6 [nucleoplasm]
(R-HSA-4754226)
0.72
10
UniProt:Q86YD7 F90A1
0.649
5
ChEBI:83406 MS-417
0.645
5
UniProt:Q15672 TWIST1
1
TWIST1 [nucleoplasm]
(R-HSA-445442)
0.623
7
UniProt:P03122 VE2
0.619
4
UniProt:P06790 VE2
0.573
2
UniProt:P04015 VE2
0.573
3
UniProt:A6NLX3 SPDE4
0.539
4
UniProt:P0DTC4 E
9
N-glycan E [endoplasmic reticulum lumen]
(R-COV-9694754)
nascent E [endoplasmic reticulum lumen]
(R-COV-9694312)
3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9694305)
Ub-3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9694423)
Ub-3xPalmC-E [endoplasmic reticulum membrane]
(R-COV-9694465)
Ub-3xPalmC-E [Golgi membrane]
(R-COV-9694687)
Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698420)
Ub-3xPalmC-E [endocytic vesicle membrane]
(R-COV-9698422)
Ub-3xPalmC-E [virion membrane]
(R-COV-9698416)
0.527
2
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