Reactome | Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Period-3 (PER3)

Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Period-3 (PER3)

Stable Identifier

R-HSA-9909374

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

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Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Period-3 (PER3)

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Phosphorylated BMAL1:CLOCK bound to the promoter of PER3 activates transcription (Matsumura and Akashi 2017). Expression of PER3 oscillates in a circadian rhythm in the suprachiasmatic nucleus, but, unlike PER1 and PER2, expression is not induced by light during the night (Li et al. 2013, and inferred from mouse homologs). Expression of PER3 peaks around mid-day, after the peak of PER1 expression and before the peak of PER2 expression (Li et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23671070	Circadian patterns of gene expression in the human brain and disruption in major depressive disorder Li, JZ, Bunney, BG, Meng, F, Hagenauer, MH, Walsh, DM, Vawter, MP, Evans, SJ, Choudary, PV, Cartagena, P, Barchas, JD, Schatzberg, AF, Jones, EG, Myers, RM, Watson, SJ, Akil, H, Bunney, WE	Proc Natl Acad Sci U S A	2013
28821614	Multiple circadian transcriptional elements cooperatively regulate cell-autonomous transcriptional oscillation of Period3, a mammalian clock gene Matsumura, R, Akashi, M	J Biol Chem	2017