Reactome | HK1 phosphorylates Mannose to Man6P

HK1 phosphorylates Mannose to Man6P

Stable Identifier

R-HSA-9909159

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ATP + D-mannose => ADP + D-mannose 6-phosphate + H(+)

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of GDP-mannose (Homo sapiens)
        
        HK1 phosphorylates Mannose to Man6P (Homo sapiens)

General

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Cytosolic hexokinase 1 (HK1) catalyzes the phosphorylation of mannose (Man) to form D-mannose 6-phosphate (Man6P). The properties of the human enzyme are inferred from those of its better-studied rat ortholog (Abraham et al. 1961, 1964).

Literature References

PubMed ID	Title	Journal	Year
14191428	EFFECT OF DIETARY CARBOHYDRATE AND GLUCOKINASE AND MANNOKINASE ACTIVITIES OF VARIOUS RAT TISSUES Abraham, IL, Abraham, S, Abraham, B	J Nutr	1964
13681085	Mannose metabolism and the demonstration of mannokinase and phosphomannoisomerase activities in the lactating rat mammary gland Abraham, S, Fitch, WM, Chaikoff, IL	Arch Biochem Biophys	1961