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FUMA [mitochondrial matrix]
Stable Identifier
R-ALL-113588
Type
Chemical Compound [SimpleEntity]
Compartment
mitochondrial matrix
Synonyms
Fumarate, fumaric acid, Trans-butenedioic acid
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
The citric acid (TCA) cycle and respiratory electron transport (Bos taurus)
Pyruvate metabolism and Citric Acid (TCA) cycle (Bos taurus)
Citric acid cycle (TCA cycle) (Bos taurus)
(S)-Malate <=> Fumarate + H2O (Bos taurus)
FUMA [mitochondrial matrix]
Fumarate + H2O <=> (S)-Malate (Bos taurus)
FUMA [mitochondrial matrix]
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Bos taurus)
FUMA [mitochondrial matrix]
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Bos taurus)
FUMA [mitochondrial matrix]
Metabolism (Caenorhabditis elegans)
The citric acid (TCA) cycle and respiratory electron transport (Caenorhabditis elegans)
Pyruvate metabolism and Citric Acid (TCA) cycle (Caenorhabditis elegans)
Citric acid cycle (TCA cycle) (Caenorhabditis elegans)
(S)-Malate <=> Fumarate + H2O (Caenorhabditis elegans)
FUMA [mitochondrial matrix]
Fumarate + H2O <=> (S)-Malate (Caenorhabditis elegans)
FUMA [mitochondrial matrix]
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Caenorhabditis elegans)
FUMA [mitochondrial matrix]
Metabolism (Canis familiaris)
The citric acid (TCA) cycle and respiratory electron transport (Canis familiaris)
Pyruvate metabolism and Citric Acid (TCA) cycle (Canis familiaris)
Citric acid cycle (TCA cycle) (Canis familiaris)
(S)-Malate <=> Fumarate + H2O (Canis familiaris)
FUMA [mitochondrial matrix]
Fumarate + H2O <=> (S)-Malate (Canis familiaris)
FUMA [mitochondrial matrix]
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Canis familiaris)
FUMA [mitochondrial matrix]
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Canis familiaris)
FUMA [mitochondrial matrix]
Metabolism (Danio rerio)
The citric acid (TCA) cycle and respiratory electron transport (Danio rerio)
Pyruvate metabolism and Citric Acid (TCA) cycle (Danio rerio)
Citric acid cycle (TCA cycle) (Danio rerio)
(S)-Malate <=> Fumarate + H2O (Danio rerio)
FUMA [mitochondrial matrix]
Fumarate + H2O <=> (S)-Malate (Danio rerio)
FUMA [mitochondrial matrix]
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Danio rerio)
FUMA [mitochondrial matrix]
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Danio rerio)
FUMA [mitochondrial matrix]
Metabolism (Dictyostelium discoideum)
The citric acid (TCA) cycle and respiratory electron transport (Dictyostelium discoideum)
Pyruvate metabolism and Citric Acid (TCA) cycle (Dictyostelium discoideum)
Citric acid cycle (TCA cycle) (Dictyostelium discoideum)
(S)-Malate <=> Fumarate + H2O (Dictyostelium discoideum)
FUMA [mitochondrial matrix]
Fumarate + H2O <=> (S)-Malate (Dictyostelium discoideum)
FUMA [mitochondrial matrix]
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Dictyostelium discoideum)
FUMA [mitochondrial matrix]
Metabolism (Drosophila melanogaster)
The citric acid (TCA) cycle and respiratory electron transport (Drosophila melanogaster)
Pyruvate metabolism and Citric Acid (TCA) cycle (Drosophila melanogaster)
Citric acid cycle (TCA cycle) (Drosophila melanogaster)
(S)-Malate <=> Fumarate + H2O (Drosophila melanogaster)
FUMA [mitochondrial matrix]
Fumarate + H2O <=> (S)-Malate (Drosophila melanogaster)
FUMA [mitochondrial matrix]
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Drosophila melanogaster)
FUMA [mitochondrial matrix]
Metabolism (Gallus gallus)
The tricarboxylic acid cycle (Gallus gallus)
fumarate + FADH2 <=> succinate + FAD (Gallus gallus)
FUMA [mitochondrial matrix]
fumarate + H2O <=> malate (Gallus gallus)
FUMA [mitochondrial matrix]
malate <=> fumarate + H2O (Gallus gallus)
FUMA [mitochondrial matrix]
succinate + FAD <=> fumarate + FADH2 (Gallus gallus)
FUMA [mitochondrial matrix]
Metabolism (Homo sapiens)
The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
Pyruvate metabolism and Citric Acid (TCA) cycle (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
(S)-Malate <=> Fumarate + H2O (Homo sapiens)
FUMA [mitochondrial matrix]
Fumarate + H2O <=> (S)-Malate (Homo sapiens)
FUMA [mitochondrial matrix]
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)
FUMA [mitochondrial matrix]
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Homo sapiens)
FUMA [mitochondrial matrix]
Metabolism (Mus musculus)
The citric acid (TCA) cycle and respiratory electron transport (Mus musculus)
Pyruvate metabolism and Citric Acid (TCA) cycle (Mus musculus)
Citric acid cycle (TCA cycle) (Mus musculus)
(S)-Malate <=> Fumarate + H2O (Mus musculus)
FUMA [mitochondrial matrix]
Fumarate + H2O <=> (S)-Malate (Mus musculus)
FUMA [mitochondrial matrix]
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Mus musculus)
FUMA [mitochondrial matrix]
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Mus musculus)
FUMA [mitochondrial matrix]
Metabolism (Rattus norvegicus)
The citric acid (TCA) cycle and respiratory electron transport (Rattus norvegicus)
Pyruvate metabolism and Citric Acid (TCA) cycle (Rattus norvegicus)
Citric acid cycle (TCA cycle) (Rattus norvegicus)
(S)-Malate <=> Fumarate + H2O (Rattus norvegicus)
FUMA [mitochondrial matrix]
Fumarate + H2O <=> (S)-Malate (Rattus norvegicus)
FUMA [mitochondrial matrix]
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Rattus norvegicus)
FUMA [mitochondrial matrix]
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Rattus norvegicus)
FUMA [mitochondrial matrix]
Metabolism (Saccharomyces cerevisiae)
The citric acid (TCA) cycle and respiratory electron transport (Saccharomyces cerevisiae)
Pyruvate metabolism and Citric Acid (TCA) cycle (Saccharomyces cerevisiae)
Citric acid cycle (TCA cycle) (Saccharomyces cerevisiae)
(S)-Malate <=> Fumarate + H2O (Saccharomyces cerevisiae)
FUMA [mitochondrial matrix]
Fumarate + H2O <=> (S)-Malate (Saccharomyces cerevisiae)
FUMA [mitochondrial matrix]
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Saccharomyces cerevisiae)
FUMA [mitochondrial matrix]
Metabolism (Schizosaccharomyces pombe)
The citric acid (TCA) cycle and respiratory electron transport (Schizosaccharomyces pombe)
Pyruvate metabolism and Citric Acid (TCA) cycle (Schizosaccharomyces pombe)
Citric acid cycle (TCA cycle) (Schizosaccharomyces pombe)
(S)-Malate <=> Fumarate + H2O (Schizosaccharomyces pombe)
FUMA [mitochondrial matrix]
Fumarate + H2O <=> (S)-Malate (Schizosaccharomyces pombe)
FUMA [mitochondrial matrix]
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Schizosaccharomyces pombe)
FUMA [mitochondrial matrix]
Metabolism (Sus scrofa)
The citric acid (TCA) cycle and respiratory electron transport (Sus scrofa)
Pyruvate metabolism and Citric Acid (TCA) cycle (Sus scrofa)
Citric acid cycle (TCA cycle) (Sus scrofa)
(S)-Malate <=> Fumarate + H2O (Sus scrofa)
FUMA [mitochondrial matrix]
Fumarate + H2O <=> (S)-Malate (Sus scrofa)
FUMA [mitochondrial matrix]
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Sus scrofa)
FUMA [mitochondrial matrix]
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Sus scrofa)
FUMA [mitochondrial matrix]
Metabolism (Xenopus tropicalis)
The citric acid (TCA) cycle and respiratory electron transport (Xenopus tropicalis)
Pyruvate metabolism and Citric Acid (TCA) cycle (Xenopus tropicalis)
Citric acid cycle (TCA cycle) (Xenopus tropicalis)
(S)-Malate <=> Fumarate + H2O (Xenopus tropicalis)
FUMA [mitochondrial matrix]
Fumarate + H2O <=> (S)-Malate (Xenopus tropicalis)
FUMA [mitochondrial matrix]
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Xenopus tropicalis)
FUMA [mitochondrial matrix]
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Xenopus tropicalis)
FUMA [mitochondrial matrix]
External Reference Information
External Reference
fumaric acid [ChEBI:18012]
Participates
as an input of
fumarate + FADH2 <=> succinate + FAD (Gallus gallus)
Fumarate + H2O <=> (S)-Malate (Homo sapiens)
Fumarate + H2O <=> (S)-Malate (Mus musculus)
Fumarate + H2O <=> (S)-Malate (Rattus norvegicus)
Fumarate + H2O <=> (S)-Malate (Canis familiaris)
Fumarate + H2O <=> (S)-Malate (Bos taurus)
Fumarate + H2O <=> (S)-Malate (Sus scrofa)
Fumarate + H2O <=> (S)-Malate (Danio rerio)
Fumarate + H2O <=> (S)-Malate (Xenopus tropicalis)
Fumarate + H2O <=> (S)-Malate (Drosophila melanogaster)
Fumarate + H2O <=> (S)-Malate (Caenorhabditis elegans)
Fumarate + H2O <=> (S)-Malate (Gallus gallus)
Fumarate + H2O <=> (S)-Malate (Schizosaccharomyces pombe)
Fumarate + H2O <=> (S)-Malate (Saccharomyces cerevisiae)
Fumarate + H2O <=> (S)-Malate (Dictyostelium discoideum)
fumarate + H2O <=> malate (Gallus gallus)
as an output of
succinate + FAD <=> fumarate + FADH2 (Gallus gallus)
(S)-Malate <=> Fumarate + H2O (Homo sapiens)
(S)-Malate <=> Fumarate + H2O (Mus musculus)
(S)-Malate <=> Fumarate + H2O (Rattus norvegicus)
(S)-Malate <=> Fumarate + H2O (Canis familiaris)
(S)-Malate <=> Fumarate + H2O (Bos taurus)
(S)-Malate <=> Fumarate + H2O (Sus scrofa)
(S)-Malate <=> Fumarate + H2O (Danio rerio)
(S)-Malate <=> Fumarate + H2O (Xenopus tropicalis)
(S)-Malate <=> Fumarate + H2O (Gallus gallus)
(S)-Malate <=> Fumarate + H2O (Drosophila melanogaster)
(S)-Malate <=> Fumarate + H2O (Caenorhabditis elegans)
(S)-Malate <=> Fumarate + H2O (Dictyostelium discoideum)
(S)-Malate <=> Fumarate + H2O (Schizosaccharomyces pombe)
(S)-Malate <=> Fumarate + H2O (Saccharomyces cerevisiae)
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Homo sapiens)
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Mus musculus)
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Rattus norvegicus)
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Canis familiaris)
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Bos taurus)
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Sus scrofa)
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Danio rerio)
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Xenopus tropicalis)
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Drosophila melanogaster)
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Caenorhabditis elegans)
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Gallus gallus)
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Schizosaccharomyces pombe)
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Saccharomyces cerevisiae)
Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Dictyostelium discoideum)
malate <=> fumarate + H2O (Gallus gallus)
This entity regulates
Positively
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR
(Xenopus tropicalis)
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR
(Danio rerio)
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR
(Sus scrofa)
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR
(Bos taurus)
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR
(Canis familiaris)
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR
(Rattus norvegicus)
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR
(Mus musculus)
ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR
(Homo sapiens)
Cross References
COMPOUND
C00122
PubChem Substance
8145602
HMDB Metabolite
HMDB0000134
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