Reactome | KCNA5 [plasma membrane]

KCNA5 [plasma membrane]

Stable Identifier

R-HSA-977472

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Potassium voltage-gated channel subfamily A member 5, KCNA5_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Voltage gated Potassium channels (Homo sapiens)
    - Activation of voltage gated Potassium channels (Homo sapiens)
      - Octamer of Voltage gated K+ channels [plasma membrane] (Homo sapiens)
        
        Voltage gated potassium channel subunits Kv1-12 [plasma membrane] (Homo sapiens)
        
        Kv1 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)
        
        KCNA5 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P22460 KCNA5

Gene Names

KCNA5

Chain

chain:1-613

Reference Genes

BioGPS Gene:3741 KCNA5

COSMIC (genes):KCNA5 KCNA5

CTD Gene:3741 KCNA5

dbSNP Gene:3741 KCNA5

ENSEMBL:ENSG00000130037 KCNA5

HGNC:6224 KCNA5

Monarch:3741 KCNA5

NCBI Gene:3741 KCNA5

OMIM:176267 KCNA5

UCSC:P22460 KCNA5

Reference Transcript

RefSeq:NM_002234.3 KCNA5

Other Identifiers

11729023_at

11729024_at

16747137

206762_PM_at

206762_at

3402040

3402041

3402042

3402043

34981_at

3741

7953278

A_14_P117017

A_14_P200772

A_23_P417173

GE57972

GO:0001508

GO:0001666

GO:0003013

GO:0005102

GO:0005215

GO:0005216

GO:0005249

GO:0005251

GO:0005267

GO:0005515

GO:0005794

GO:0005886

GO:0005901

GO:0006811

GO:0006813

GO:0007219

GO:0008076

GO:0008092

GO:0009612

GO:0009986

GO:0014704

GO:0015271

GO:0016020

GO:0019229

GO:0019901

GO:0030018

GO:0034702

GO:0034705

GO:0042391

GO:0042542

GO:0043226

GO:0043266

GO:0045121

GO:0046691

GO:0048471

GO:0050796

GO:0051259

GO:0051260

GO:0051393

GO:0051481

GO:0055075

GO:0055085

GO:0055093

GO:0060081

GO:0060372

GO:0065003

GO:0071805

GO:0086014

GO:0086050

GO:0086052

GO:0086087

GO:0086089

GO:0086090

GO:0086091

GO:0097110

GO:0097623

GO:0098914

GO:1900087

GO:2000288

HMNXSV003006713

ILMN_1790508

M55513_s_at

PH_hs_0009051

TC12000071.hg

g4504818_3p_at

Participates

as a member of

Kv1 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)

as a component of

KCNA5 tetramer [plasma membrane] (Homo sapiens)

Inferred To

Kcna5 [plasma membrane] (Mus musculus)

Kcna5 [plasma membrane] (Rattus norvegicus)

kcna5 [plasma membrane] (Xenopus tropicalis)

Sh [plasma membrane] (Drosophila melanogaster)

K1 [plasma membrane] (Plasmodium falciparum)

shk-1 [plasma membrane] (Caenorhabditis elegans)

KCNA5 [plasma membrane] (Bos taurus)

KCNA5 [plasma membrane] (Canis familiaris)

KCNA5 [plasma membrane] (Gallus gallus)

KCNA5 [plasma membrane] (Sus scrofa)

Cross References

ZINC - World Drugs

KCNA5_HUMAN

Guide to Pharmacology - Targets

542

ENSEMBL

ENST00000252321, ENSP00000252321

OpenTargets

ENSG00000130037

ZINC - FDA approved

KCNA5_HUMAN

ZINC - Substances

KCNA5_HUMAN

ZINC - Biogenic

KCNA5_HUMAN

ZINC target

P22460

PRO

P22460

ZINC - Investigational

KCNA5_HUMAN

HPA

ENSG00000130037-KCNA5

Pharos - Targets

P22460

Orphanet

KCNA5

ZINC - Predictions - Purchasable

KCNA5_HUMAN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9ULK5 VANGL2	2	VANGL2 [plasma membrane] (R-HSA-3965373) pS5,S82,S84-VANGL2 [plasma membrane] (R-HSA-4551547)	0.527	2
UniProt:Q86XL3 ANKLE2	2	Ac-K302-ANKLE2 [endoplasmic reticulum membrane] (R-HSA-9667946) ANKLE2 [endoplasmic reticulum membrane] (R-HSA-2529000)	0.527	2
UniProt:Q9UPQ8 DOLK	6	DOLK [endoplasmic reticulum membrane] (R-HSA-449274) DOLK M1I [endoplasmic reticulum membrane] (R-HSA-4755593) DOLK H408D [endoplasmic reticulum membrane] (R-HSA-4755548) DOLK C99S [endoplasmic reticulum membrane] (R-HSA-4755602) DOLK W304C [endoplasmic reticulum membrane] (R-HSA-4755557) DOLK Y441S [endoplasmic reticulum membrane] (R-HSA-4755590)	0.527	2
UniProt:A0PJW6 TMEM223	1	TMEM223 [mitochondrial inner membrane] (R-HSA-9865797)	0.527	2