PHGDH tetramer dehydrogenates 3PG

Stable Identifier
R-HSA-977348
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
3-phosphoglycerate is dehydrogenated
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Serine biosynthesis starts from 3-phosphoglycerate (3PG), a glycolysis intermediate. Its dehydrogenation to 3-phosphonooxypyruvic acid (3POPA) is catalysed by tetrameric phosphoglycerate dehydrogenase (PHGDH). (Tabatabaie et al. 2009).

Literature References
PubMed ID Title Journal Year
19235232 Novel mutations in 3-phosphoglycerate dehydrogenase (PHGDH) are distributed throughout the protein and result in altered enzyme kinetics

Berger, R, Geboers, AJ, van den Berg, IE, Klomp, LW, Tabatabaie, L, de Koning, TJ

Hum Mutat 2009
Participants
Participates
Catalyst Activity

phosphoglycerate dehydrogenase activity of PHGDH tetramer [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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