Reactome | PHGDH tetramer dehydrogenates 3PG

PHGDH tetramer dehydrogenates 3PG

Stable Identifier

R-HSA-977348

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(2R)-3-phosphoglycerate + NAD(+) => 3-phosphooxypyruvate + H(+) + NADH, 3-phosphoglycerate is dehydrogenated

ReviewStatus

5/5

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Serine biosynthesis starts from 3-phosphoglycerate (3PG), a glycolysis intermediate. Its dehydrogenation to 3-phosphonooxypyruvic acid (3POPA) is catalysed by tetrameric phosphoglycerate dehydrogenase (PHGDH). (Tabatabaie et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19235232	Novel mutations in 3-phosphoglycerate dehydrogenase (PHGDH) are distributed throughout the protein and result in altered enzyme kinetics Tabatabaie, L, de Koning, TJ, Geboers, AJ, van den Berg, IE, Berger, R, Klomp, LW	Hum Mutat	2009