PHGDH tetramer dehydrogenates 3PG

Stable Identifier
R-HSA-977348
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
3-phosphoglycerate is dehydrogenated
ReviewStatus
5/5
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PHGDH tetramer dehydrogenates 3PG
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Serine biosynthesis starts from 3-phosphoglycerate (3PG), a glycolysis intermediate. Its dehydrogenation to 3-phosphonooxypyruvic acid (3POPA) is catalysed by tetrameric phosphoglycerate dehydrogenase (PHGDH). (Tabatabaie et al. 2009).
Literature References
PubMed ID Title Journal Year
19235232 Novel mutations in 3-phosphoglycerate dehydrogenase (PHGDH) are distributed throughout the protein and result in altered enzyme kinetics

Berger, R, Geboers, AJ, van den Berg, IE, Klomp, LW, Tabatabaie, L, de Koning, TJ

Hum Mutat 2009
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Catalyst Activity

phosphoglycerate dehydrogenase activity of PHGDH tetramer [cytosol]

Physical Entity
PHGDH tetramer [cytosol] (Homo sapiens)
Activity
phosphoglycerate dehydrogenase activity (GO:0004617)
Orthologous Events
PHGDH tetramer dehydrogenates 3PG (Bos taurus)
PHGDH tetramer dehydrogenates 3PG (Caenorhabditis elegans)
PHGDH tetramer dehydrogenates 3PG (Canis familiaris)
PHGDH tetramer dehydrogenates 3PG (Drosophila melanogaster)
PHGDH tetramer dehydrogenates 3PG (Mus musculus)
PHGDH tetramer dehydrogenates 3PG (Rattus norvegicus)
PHGDH tetramer dehydrogenates 3PG (Sus scrofa)
PHGDH tetramer dehydrogenates 3PG (Xenopus tropicalis)
Cross References
Rhea
Authored
Stephan, R  (2010-10-16)
Reviewed
D'Eustachio, P  (2011-10-26)
Created
Jassal, B  (2010-10-18)
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