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ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
Stable Identifier
R-HSA-9766542
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
CUL3:RBX1 ubiquitinates KEAP1 (Homo sapiens)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
SESN1,SESN1 bind SQSTM1 and KEAP1 (Homo sapiens)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
Participants
components
KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer [cytosol]
(Homo sapiens)
Participates
as an output of
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Homo sapiens)
as an input of
SESN1,SESN1 bind SQSTM1 and KEAP1 (Homo sapiens)
as a component of
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
This entity regulates
Negatively
NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1
(Homo sapiens)
Inferred To
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Bos taurus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Caenorhabditis elegans)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Canis familiaris)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Danio rerio)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Dictyostelium discoideum)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Drosophila melanogaster)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Gallus gallus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Mus musculus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Rattus norvegicus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Sus scrofa)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Xenopus tropicalis)
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