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KEAP1:NEDD8-CUL3:RBX1 [cytosol]
Stable Identifier
R-HSA-8932333
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
CUL3:RBX1 ubiquitinates KEAP1 (Homo sapiens)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Homo sapiens)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
SESN1,SESN1 bind SQSTM1 and KEAP1 (Homo sapiens)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Homo sapiens)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
Participants
components
G76-NEDD8-K712-CUL3 [cytosol]
(Homo sapiens)
KEAP1 [cytosol]
(Homo sapiens)
RBX1 [cytosol]
(Homo sapiens)
Participates
as an input of
NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 (Homo sapiens)
p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Homo sapiens)
as a component of
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
as an output of
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Homo sapiens)
Inferred To
KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Caenorhabditis elegans)
KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Dictyostelium discoideum)
KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Gallus gallus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Mus musculus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(Xenopus tropicalis)
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