Reactome | SESN1,SESN1 bind SQSTM1 and KEAP1

SESN1,SESN1 bind SQSTM1 and KEAP1

Stable Identifier

R-HSA-9766687

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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SESN1 and SESN2 are proteins with roles in oxidative stress response. Both SESN1 and SESN2 interact with SQSTM1 in the context of a KEAP1:CUL3:RBX1 complex to promote the degradation of KEAP1 by selective autophagy (Bae et al, 2013; Ro et al, 2014). SESN1 and SESN2 may increase the binding affinity of SQSTM1 for its KEAP1 substrate (Bae et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
25040165	Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1 Lee, JH, Semple, IA, Ro, SH, Park, H, Park, H, Kim, M, Park, HW, Kim, JS	FEBS J	2014
23274085	Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage Lim, JM, Park, YN, Lee, HE, Sung, SH, Bae, SH, Kang, D, Oh, SY, Lee, SK, Rhee, SG	Cell Metab	2013