SESN1 and SESN2 are proteins with roles in oxidative stress response. Both SESN1 and SESN2 interact with SQSTM1 in the context of a KEAP1:CUL3:RBX1 complex to promote the degradation of KEAP1 by selective autophagy (Bae et al, 2013; Ro et al, 2014). SESN1 and SESN2 may increase the binding affinity of SQSTM1 for its KEAP1 substrate (Bae et al, 2013).
Lee, JH, Semple, IA, Ro, SH, Park, H, Park, H, Kim, M, Park, HW, Kim, JS
Lim, JM, Park, YN, Lee, HE, Sung, SH, Bae, SH, Kang, D, Oh, SY, Lee, SK, Rhee, SG
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