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KLHL21 [cytosol]
Stable Identifier
R-HSA-976026
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Kelch-like protein 21, KLH21_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL21 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UJP4 KLHL21
Gene Names
KLHL21, KIAA0469
Chain
chain:1-597
Reference Genes
BioGPS Gene:9903 KLHL21
COSMIC (genes):KLHL21 KLHL21
CTD Gene:9903 KLHL21
dbSNP Gene:9903 KLHL21
ENSEMBL:ENSG00000162413 KLHL21
ENSEMBL:ENSG00000162413.17 KLHL21
HGNC:29041 KLHL21
KEGG Gene (Homo sapiens):9903 KLHL21
Monarch:9903 KLHL21
NCBI Gene:9903 KLHL21
OMIM:616262 KLHL21
UCSC:Q9UJP4 KLHL21
Reference Transcript
RefSeq:NM_014851.3 KLHL21
Other Identifiers
11718984_a_at
11747822_a_at
16681210
203068_PM_at
203068_at
2394818
2394819
2394820
2394821
2394822
2394823
2394824
2394825
2394827
2394828
2394829
37230_at
7912102
9903
A_23_P201478
A_23_P341223
GE81962
GO:0000910
GO:0003824
GO:0004842
GO:0005515
GO:0005737
GO:0005819
GO:0005827
GO:0005829
GO:0005856
GO:0007049
GO:0016567
GO:0016740
GO:0031463
GO:0032465
GO:0035853
GO:0036211
GO:0043226
GO:0051301
GO:0097602
GO:0140096
HMNXSV003009440
HMNXSV003047714
ILMN_1692785
PH_hs_0000800
TC01002155.hg
g7662139_3p_at
Participates
as a member of
BTB proteins [cytosol] (Homo sapiens)
Inferred To
klhl21 [cytosol]
(Danio rerio)
klhl21 [cytosol]
(Xenopus tropicalis)
GAN [cytosol]
(Dictyostelium discoideum)
KLHL21 [cytosol]
(Bos taurus)
KLHL21 [cytosol]
(Canis familiaris)
KLHL21 [cytosol]
(Gallus gallus)
KLHL21 [cytosol]
(Sus scrofa)
rike-1 [cytosol]
(Caenorhabditis elegans)
Klhl21 [cytosol]
(Mus musculus)
Klhl21 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_055666.2
OpenTargets
ENSG00000162413
HPA
ENSG00000162413-KLHL21
GeneCards
Q9UJP4
Ensembl
ENSP00000366886
,
ENST00000377663
,
ENSG00000162413
,
ENST00000377658
,
ENSP00000366891
PRO
Q9UJP4
Pharos - Targets
Q9UJP4
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